Vaccines for immunoprevention of cancer
Tomohiro Enokida,1 Alvaro Moreira,1,2 and Nina Bhardwaj1,2,3
1Department of Medicine, Precision Immunology Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
2The Kimberly and Eric J. Waldman Department of Dermatology at Mount Sinai, New York, New York, USA.
3Extramural member of the Parker Institute for Cancer Immunotherapy, San Francisco, California, USA.
Address correspondence to: Nina Bhardwaj, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, Hess Center for Science and Medicine, 1470 Madison Avenue, Room 116, New York, New York 10029, USA. Phone: 212.824.8427; Email: nina.bhardwaj@mssm.edu.
Authorship note: TE and AM contributed equally to this work.
Find articles by Enokida, T. in: JCI | PubMed | Google Scholar
1Department of Medicine, Precision Immunology Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
2The Kimberly and Eric J. Waldman Department of Dermatology at Mount Sinai, New York, New York, USA.
3Extramural member of the Parker Institute for Cancer Immunotherapy, San Francisco, California, USA.
Address correspondence to: Nina Bhardwaj, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, Hess Center for Science and Medicine, 1470 Madison Avenue, Room 116, New York, New York 10029, USA. Phone: 212.824.8427; Email: nina.bhardwaj@mssm.edu.
Authorship note: TE and AM contributed equally to this work.
Find articles by Moreira, A. in: JCI | PubMed | Google Scholar
1Department of Medicine, Precision Immunology Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
2The Kimberly and Eric J. Waldman Department of Dermatology at Mount Sinai, New York, New York, USA.
3Extramural member of the Parker Institute for Cancer Immunotherapy, San Francisco, California, USA.
Address correspondence to: Nina Bhardwaj, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, Hess Center for Science and Medicine, 1470 Madison Avenue, Room 116, New York, New York 10029, USA. Phone: 212.824.8427; Email: nina.bhardwaj@mssm.edu.
Authorship note: TE and AM contributed equally to this work.
Find articles by Bhardwaj, N. in: JCI | PubMed | Google Scholar
Published May 3, 2021 - More info
J Clin Invest. 2021;131(9):e146956. https://doi.org/10.1172/JCI146956.
© 2021 American Society for Clinical Investigation
The immunoprevention of cancer and cancer recurrence is an important area of concern for the scientific community and society as a whole. Researchers have been working for decades to develop vaccines with the potential to alleviate these health care and economic burdens. So far, vaccines have made more progress in preventing cancer than in eliminating already established cancer. In particular, vaccines targeting oncogenic viruses, such as the human papillomavirus and the hepatitis B virus, are exceptional examples of successful prevention of virus-associated cancers, such as cervical cancer and hepatocellular carcinoma. Cancer-preventive vaccines targeting nonviral antigens, such as tumor-associated antigens and neoantigens, are also being extensively tested. Here, we review the currently approved preventive cancer vaccines; discuss the challenges in this field by covering ongoing preclinical and clinical human trials in various cancers; and address various issues related to maximizing cancer vaccine benefit.
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