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Vaccines for immunoprevention of cancer
Tomohiro Enokida, … , Alvaro Moreira, Nina Bhardwaj
Tomohiro Enokida, … , Alvaro Moreira, Nina Bhardwaj
Published May 3, 2021
Citation Information: J Clin Invest. 2021;131(9):e146956. https://doi.org/10.1172/JCI146956.
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Review

Vaccines for immunoprevention of cancer

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Abstract

The immunoprevention of cancer and cancer recurrence is an important area of concern for the scientific community and society as a whole. Researchers have been working for decades to develop vaccines with the potential to alleviate these health care and economic burdens. So far, vaccines have made more progress in preventing cancer than in eliminating already established cancer. In particular, vaccines targeting oncogenic viruses, such as the human papillomavirus and the hepatitis B virus, are exceptional examples of successful prevention of virus-associated cancers, such as cervical cancer and hepatocellular carcinoma. Cancer-preventive vaccines targeting nonviral antigens, such as tumor-associated antigens and neoantigens, are also being extensively tested. Here, we review the currently approved preventive cancer vaccines; discuss the challenges in this field by covering ongoing preclinical and clinical human trials in various cancers; and address various issues related to maximizing cancer vaccine benefit.

Authors

Tomohiro Enokida, Alvaro Moreira, Nina Bhardwaj

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Figure 1

Model for prophylactic cancer vaccine.

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Model for prophylactic cancer vaccine.
Vaccines can work as primary prev...
Vaccines can work as primary prevention in healthy people to reduce premalignant and cancer occurrence and as tertiary prevention for cancer patients who received curative treatment to reduce recurrence.

Copyright © 2022 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

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