Commentary 10.1172/JCI144685

SARS-CoV-2 B cell receptor signatures in at-risk populations

Andrew I. Flyak

Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA.

Address correspondence to: Andrew Flyak, Division of Biology and Biological Engineering, California, Institute of Technology, Pasadena, California, 91125, USA. Phone: 626.395.8351; Email: flyaka@caltech.edu.

Find articles by Flyak, A. in: JCI | PubMed | Google Scholar |

Published November 20, 2020 - More info

Published in Volume 131, Issue 1 on January 4, 2021
J Clin Invest. 2021;131(1):e144685. https://doi.org/10.1172/JCI144685.
© 2021 American Society for Clinical Investigation
Published November 20, 2020 - Version history
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Many individuals possess B cells capable of recognizing epitopes on the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this issue of the JCI, Paschold and Simnica et al. interrogated the frequency of SARS-CoV-2–specific B cell receptor rearrangements in healthy subjects based on age and cancer status. The authors found that while SARS-CoV-2–specific antibody signatures can be identified in the repertoires of young, healthy individuals, such sequences are less frequent in elderly subjects or patients with cancer. Overall, this study sheds light on B cell repertoire restrictions that might lead to an unfavorable clinical course of coronavirus disease 2019 infection in at-risk populations.

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