Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Author's Takes
  • Reviews
    • View all reviews ...
    • Immune Environment in Glioblastoma (Upcoming)
    • Korsmeyer Award 25th Anniversary Collection (Jan 2023)
    • Aging (Jul 2022)
    • Next-Generation Sequencing in Medicine (Jun 2022)
    • New Therapeutic Targets in Cardiovascular Diseases (Mar 2022)
    • Immunometabolism (Jan 2022)
    • Circadian Rhythm (Oct 2021)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Commentaries
    • Research letters
    • Letters to the editor
    • Editorials
    • Viewpoint
    • Top read articles
  • Clinical Medicine
  • JCI This Month
    • Current issue
    • Past issues

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Author's Takes
  • In-Press Preview
  • Commentaries
  • Research letters
  • Letters to the editor
  • Editorials
  • Viewpoint
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences
Valerie A. Fadok, … , Donna L. Bratton, Peter M. Henson
Valerie A. Fadok, … , Donna L. Bratton, Peter M. Henson
Published October 1, 2001
Citation Information: J Clin Invest. 2001;108(7):957-962. https://doi.org/10.1172/JCI14122.
View: Text | PDF
Perspective

Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences

  • Text
  • PDF
Abstract

Authors

Valerie A. Fadok, Donna L. Bratton, Peter M. Henson

×

Figure 1

Options: View larger image (or click on image) Download as PowerPoint
A hypothetical model for the role of a newly described receptor for phos...
A hypothetical model for the role of a newly described receptor for phosphatidylserine (PS) (26) in modulating inflammation and immune response. Engulfment of microbial organisms that fail to express PS externally does not engage the PS receptor (PSR); instead, receptors are stimulated by the microbe or its products that transduce proinflammatory signals. These include receptors for immunoglobulin, complement, collectins, endotoxin, etc. In contrast, when apoptotic cells are recognized, they expose PS, thus engaging the PSR, which provides an anti-inflammatory signal. TLR, toll-like receptor.

Copyright © 2023 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts