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What are the mechanisms underlying vaping-induced lung injury?
Laura E. Crotty Alexander, … , Amy L. Bellinghausen, Michelle N. Eakin
Laura E. Crotty Alexander, … , Amy L. Bellinghausen, Michelle N. Eakin
Published May 11, 2020
Citation Information: J Clin Invest. 2020;130(6):2754-2756. https://doi.org/10.1172/JCI138644.
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What are the mechanisms underlying vaping-induced lung injury?

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Abstract

Authors

Laura E. Crotty Alexander, Amy L. Bellinghausen, Michelle N. Eakin

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Figure 1

Mechanisms underlying lung injury in EVALI.

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Mechanisms underlying lung injury in EVALI.
(A) In the panel on the left...
(A) In the panel on the left, cells of the lung are damaged by one chemical inhaled within e-cigarette aerosols. This cell damage leads to epithelial and endothelial cell necrosis (indicated by a yellow “X”). An alternative hypothesis is depicted on the right, in which inhalation of chemicals common in e-cigarette aerosols (propylene glycol, glycerin, nicotine, or THC) alters the inflammatory state of the lungs, including changing alveolar macrophages to a proinflammatory phenotype with the release of inflammatory cytokines (indicated by yellow circles), such that a second hit causes a pathologic inflammatory response. (B) The immune state of the lungs is known to be altered by the chronic, daily inhalation of e-cigarette aerosols. It is likely that vitamin E is directly cytotoxic to lung cells (indicated by a yellow “X”), leading to necrosis, neutrophil recruitment and activation resulting in collateral damage, and noncardiac pulmonary edema. Illustration credit: Rachel Davidowitz. H&E-stained lung tissues are from the UCSD Liebow Collection, 1974.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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