Commentary 10.1172/JCI128745

Trim the gut, lose the weight — and the bone

Soravis Osataphan and Mary Elizabeth Patti

Research Division, Joslin Diabetes Center, and Harvard Medical School, Boston, Massachusetts, USA.

Address correspondence to: Mary Elizabeth Patti, 1 Joslin Place, Room 620, Boston, Massachusetts 02215, USA. Phone: 617.309.2635; Email: mary.elizabeth.patti@joslin.harvard.edu.

Find articles by Osataphan, S. in: JCI | PubMed | Google Scholar | Orcid 24x24

Research Division, Joslin Diabetes Center, and Harvard Medical School, Boston, Massachusetts, USA.

Address correspondence to: Mary Elizabeth Patti, 1 Joslin Place, Room 620, Boston, Massachusetts 02215, USA. Phone: 617.309.2635; Email: mary.elizabeth.patti@joslin.harvard.edu.

Find articles by Patti, M. in: JCI | PubMed | Google Scholar | Orcid 24x24

First published May 6, 2019 - More info

J Clin Invest. https://doi.org/10.1172/JCI128745.
© 2019 American Society for Clinical Investigation
First published May 6, 2019 - Version history

Vertical sleeve gastrectomy (VSG) is an effective therapeutic approach for obesity and type 2 diabetes but is associated with osteoporosis. In this issue of the JCI, Li et al. report that VSG rapidly reduces bone mass, as observed in humans, via rapid demineralization and decreased bone formation, independent of weight loss or Ca2+/vitamin D deficiency. VSG also reduces bone marrow adipose tissue, in part via increased granulocyte–colony stimulating factor (G-CSF). The interplay between VSG-mediated effects on systemic metabolism and bone biology remain to be investigated. These findings suggest novel mechanisms and therapeutic targets for bariatric surgery–induced osteoporosis.

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