Commentary 10.1172/JCI125616

New vascular insights into premature aging

Charles J. Lowenstein and J. Allen Bennett

Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA.

Address correspondence to: Charles J. Lowenstein, 601 Elmwood Avenue, Box CVRI, Rochester, New York 14624, USA. Phone: 585.276.5077; Email: charles_lowenstein@urmc.rochester.edu.

Find articles by Lowenstein, C. in: JCI | PubMed | Google Scholar |

Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA.

Address correspondence to: Charles J. Lowenstein, 601 Elmwood Avenue, Box CVRI, Rochester, New York 14624, USA. Phone: 585.276.5077; Email: charles_lowenstein@urmc.rochester.edu.

Find articles by Bennett, J. in: JCI | PubMed | Google Scholar

First published December 18, 2018 - More info

Published in Volume 129, Issue 2 on February 1, 2019
J Clin Invest. 2019;129(2):492–493. https://doi.org/10.1172/JCI125616.
Copyright © 2019, American Society for Clinical Investigation
First published December 18, 2018 - Version history

Hutchinson-Gilford progeria syndrome (HGPS) is a fatal disease characterized by premature aging in which young children fail to thrive and adolescents die from myocardial infarction or stroke. The pathogenesis of HGPS is studied intensively because the mechanisms of premature aging may lead to a better understanding of normal aging. In this issue of the JCI, Osmanagic-Myers and colleagues identify the cellular mechanisms that lead to vascular abnormalities and death in children with HGPS.

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