Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Therapeutic applications of transcription factor decoy oligonucleotides
Michael J. Mann, Victor J. Dzau
Michael J. Mann, Victor J. Dzau
Published November 1, 2000
Citation Information: J Clin Invest. 2000;106(9):1071-1075. https://doi.org/10.1172/JCI11459.
View: Text | PDF
Perspective

Therapeutic applications of transcription factor decoy oligonucleotides

  • Text
  • PDF
Abstract

Authors

Michael J. Mann, Victor J. Dzau

×

Figure 1

Options: View larger image (or click on image) Download as PowerPoint
The decoy oligonucleotide approach to block the function of the transcri...
The decoy oligonucleotide approach to block the function of the transcription factor E2F. In quiescent cells (a), the factor is sequestered in a protein complex. During cell cycle progression (b), the complex is phosphorylated and free E2F is released. The factor binds to its consensus binding sequence in the promoter regions of multiple cell cycle regulatory genes. The introduction into the nucleus of decoy oligonucleotides that bear the consensus binding sequence (c) prevents interaction of the factor with its promoter targets, thus inhibiting the upregulation of cell cycle genes and blocking proliferation.

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts