Advertisement

Free access | 10.1172/JCI110679

Mechanisms of K+ Transport in Isolated Turtle Urinary Bladder: INDUCTION OF ACTIVE K+ SECRETION IN A K+-ABSORBING EPITHELIUM

Russell F. Husted and Philip R. Steinmetz

Departments of Medicine, University of Iowa, Iowa City, Iowa 52242

University of Connecticut, Farmington, Connecticut 06032

Find articles by Husted, R. in: PubMed | Google Scholar

Departments of Medicine, University of Iowa, Iowa City, Iowa 52242

University of Connecticut, Farmington, Connecticut 06032

Find articles by Steinmetz, P. in: PubMed | Google Scholar

Published October 1, 1982 - More info

Published in Volume 70, Issue 4 on October 1, 1982
J Clin Invest. 1982;70(4):832–834. https://doi.org/10.1172/JCI110679.
© 1982 The American Society for Clinical Investigation
Published October 1, 1982 - Version history
View PDF
Abstract

Transepithelial K+ movement was studied in vitro in the short-circuited turtle bladder by increasing luminal K+ permeability and by inhibiting the basolateral Na/K pump. Luminal addition of amphotericin B caused net K+ secretion (180±52 nmol/h) compared with net K+ absorption (42±6 nmol/h) in control bladders. Serosal ouabain and luminal amiloride abolished K+ secretion in amphotericin-treated bladders; ouabain restored net absorption (45±16 nmol/h). The direction and rate of net K+ transport are controlled by the relative K+ permeabilities and the Na/K pump sites at the two cell membranes of the epithelium.

Browse pages

Click on an image below to see the page. View PDF of the complete article

Version history
  • Version 1 (October 1, 1982): No description
Advertisement
Advertisement