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Rapid Publication Free access | 10.1172/JCI110190

Epidermal growth factor receptor number decreases during rat liver regeneration.

H S Earp and E J O'Keefe

Find articles by Earp, H. in: JCI | PubMed | Google Scholar

Find articles by O'Keefe, E. in: JCI | PubMed | Google Scholar

Published May 1, 1981 - More info

Published in Volume 67, Issue 5 on May 1, 1981
J Clin Invest. 1981;67(5):1580–1583. https://doi.org/10.1172/JCI110190.
© 1981 The American Society for Clinical Investigation
Published May 1, 1981 - Version history
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Abstract

The potential role of epidermal growth factor (EGF) in the regulation of rat liver regeneration was examined by assessing the binding of 125I-EGF to hepatic membranes isolated at various times after partial hepatectomy. The results demonstrated a fall in 125I-EGF binding detectable as early as 8 h after partial hepatectomy. The nadir in EGF binding, less than 40% of that observed in sham-operated control rats, was seen 36 and 48 h after partial hepatectomy. Scatchard analysis showed that the decrease in binding capacity was due to a fall in receptor number. The specificity of the observed loss of EGF receptors was substantiated in parallel studies of 125I-insulin and 125I-wheat germ lectin binding; the binding of these ligands did not decrease appreciably during liver regeneration. The data are consistent with the hypothesis that EGF or a similar substance is one component of the complex humoral signal that regulates liver regeneration.

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