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Free access | 10.1172/JCI109989
Section of Hematology, Medical Service, Veterans Administration Medical Center and University of Washington, Seattle, Washington 98195
Section of Oncology, Medical Service, Veterans Administration Medical Center and University of Washington, Seattle, Washington 98195
Section of Medical Genetics, Medical Service, Veterans Administration Medical Center and University of Washington, Seattle, Washington 98195
The Cardeza Foundation, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
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Section of Hematology, Medical Service, Veterans Administration Medical Center and University of Washington, Seattle, Washington 98195
Section of Oncology, Medical Service, Veterans Administration Medical Center and University of Washington, Seattle, Washington 98195
Section of Medical Genetics, Medical Service, Veterans Administration Medical Center and University of Washington, Seattle, Washington 98195
The Cardeza Foundation, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
Find articles by Singer, J. in: JCI | PubMed | Google Scholar
Section of Hematology, Medical Service, Veterans Administration Medical Center and University of Washington, Seattle, Washington 98195
Section of Oncology, Medical Service, Veterans Administration Medical Center and University of Washington, Seattle, Washington 98195
Section of Medical Genetics, Medical Service, Veterans Administration Medical Center and University of Washington, Seattle, Washington 98195
The Cardeza Foundation, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
Find articles by Catalano, P. in: JCI | PubMed | Google Scholar
Section of Hematology, Medical Service, Veterans Administration Medical Center and University of Washington, Seattle, Washington 98195
Section of Oncology, Medical Service, Veterans Administration Medical Center and University of Washington, Seattle, Washington 98195
Section of Medical Genetics, Medical Service, Veterans Administration Medical Center and University of Washington, Seattle, Washington 98195
The Cardeza Foundation, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
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Section of Hematology, Medical Service, Veterans Administration Medical Center and University of Washington, Seattle, Washington 98195
Section of Oncology, Medical Service, Veterans Administration Medical Center and University of Washington, Seattle, Washington 98195
Section of Medical Genetics, Medical Service, Veterans Administration Medical Center and University of Washington, Seattle, Washington 98195
The Cardeza Foundation, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
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Section of Hematology, Medical Service, Veterans Administration Medical Center and University of Washington, Seattle, Washington 98195
Section of Oncology, Medical Service, Veterans Administration Medical Center and University of Washington, Seattle, Washington 98195
Section of Medical Genetics, Medical Service, Veterans Administration Medical Center and University of Washington, Seattle, Washington 98195
The Cardeza Foundation, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
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Section of Hematology, Medical Service, Veterans Administration Medical Center and University of Washington, Seattle, Washington 98195
Section of Oncology, Medical Service, Veterans Administration Medical Center and University of Washington, Seattle, Washington 98195
Section of Medical Genetics, Medical Service, Veterans Administration Medical Center and University of Washington, Seattle, Washington 98195
The Cardeza Foundation, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
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Section of Hematology, Medical Service, Veterans Administration Medical Center and University of Washington, Seattle, Washington 98195
Section of Oncology, Medical Service, Veterans Administration Medical Center and University of Washington, Seattle, Washington 98195
Section of Medical Genetics, Medical Service, Veterans Administration Medical Center and University of Washington, Seattle, Washington 98195
The Cardeza Foundation, Thomas Jefferson University, Philadelphia, Pennsylvania 19107
Find articles by Fialkow, P. in: JCI | PubMed | Google Scholar
Published December 1, 1980 - More info
Further in vitro studies of hematopoietic regulation were carried out in two patients with polycythemia vera who were also heterozygotes (GdB/GdA) for glucose-6-phosphate-dehydrogenase (G-6-PD). While only G-6-PD type A was detectable in circulating erythrocytes, granulocytes and platelets, cultures of peripheral blood and marrow from one patient revealed a substantial number of G-6-PD type B erythroid burst-forming units (BFU-E) and granulocyte/macrophage colony-forming units. Detailed analysis demonstrated: (a) where detectable, normal BFU-E and granulocyte/macrophage colony-forming units were found with similar frequencies; (b) the same frequencies for normal progenitors characterized cultures of peripheral blood and marrow; (c) inhibition of normal erythroid differentiation between BFU-E and the more mature erythroid colony-forming unit; (d) a decline in the prevalence of normal colony-forming units with time, suggesting that disease progression is associated with further suppression of normal hematopoiesis by products of the abnormal clone.