Advertisement

Free access | 10.1172/JCI109852

Antibody-dependent Mononuclear Cell-mediated Antimeningococcal Activity: COMPARISON OF THE EFFECTS OF CONVALESCENT AND POSTIMMUNIZATION IMMUNOGLOBULINS G, M, AND A

George H. Lowell, Lynette F. Smith, J. McLeod Griffiss, Brenda L. Brandt, and Richard P. MacDermott

Department of Bacterial Diseases, Walter Reed Army Institute of Research, Washington, D. C. 20012

Department of Immunology, Walter Reed Army Institute of Research, Washington, D. C. 20012

Department of Gastroenterology, Walter Reed Army Institute of Research, Washington, D. C. 20012

Find articles by Lowell, G. in: PubMed | Google Scholar

Department of Bacterial Diseases, Walter Reed Army Institute of Research, Washington, D. C. 20012

Department of Immunology, Walter Reed Army Institute of Research, Washington, D. C. 20012

Department of Gastroenterology, Walter Reed Army Institute of Research, Washington, D. C. 20012

Find articles by Smith, L. in: PubMed | Google Scholar

Department of Bacterial Diseases, Walter Reed Army Institute of Research, Washington, D. C. 20012

Department of Immunology, Walter Reed Army Institute of Research, Washington, D. C. 20012

Department of Gastroenterology, Walter Reed Army Institute of Research, Washington, D. C. 20012

Find articles by Griffiss, J. in: PubMed | Google Scholar

Department of Bacterial Diseases, Walter Reed Army Institute of Research, Washington, D. C. 20012

Department of Immunology, Walter Reed Army Institute of Research, Washington, D. C. 20012

Department of Gastroenterology, Walter Reed Army Institute of Research, Washington, D. C. 20012

Find articles by Brandt, B. in: PubMed | Google Scholar

Department of Bacterial Diseases, Walter Reed Army Institute of Research, Washington, D. C. 20012

Department of Immunology, Walter Reed Army Institute of Research, Washington, D. C. 20012

Department of Gastroenterology, Walter Reed Army Institute of Research, Washington, D. C. 20012

Find articles by MacDermott, R. in: PubMed | Google Scholar

Published August 1, 1980 - More info

Published in Volume 66, Issue 2 on August 1, 1980
J Clin Invest. 1980;66(2):260–267. https://doi.org/10.1172/JCI109852.
© 1980 The American Society for Clinical Investigation
Published August 1, 1980 - Version history
View PDF
Abstract

We have compared the abilities of immunoglobulin (Ig)G, IgM, and IgA to induce either mononuclear cell-mediated (complement-independent) or complement-mediated (cell-free) antibacterial activity against group C meningococci. In each of these assays, immunoglobulins purified from the sera of individuals immunized with meningococcal group C polysaccharide were compared with those purified from sera of patients convalescing from disseminated meningococcal disease. Our data support three conclusions. First, although nonbactericidal in cooperation with complement, IgA can induce cell-mediated antibacterial activity as well as IgG. Second, the amount of IgG required to induce cell-mediated antibacterial activity is similar to the amount required for complement-mediated killing. Third, although the amount of either postimmunization or convalescent IgM required to induce complement-mediated killing is 16- to 20-fold less than the amount of respective IgG required, IgM is inferior to IgG in its ability to induce cell-mediated antibacterial activity because in the cell-mediated system (a) postimmunization IgM is ineffective; (b) the amount of convalescent IgM required for minimal activity is eightfold more than the amount of convalescent IgG required; and (c) the maximal antibacterial index induced by convalescent IgM is 50% less than that which can be induced by IgG. These data suggest that IgG and IgA may play a greater role than IgM in mononuclear cell-mediated antibacterial host immune defense.

Browse pages

Click on an image below to see the page. View PDF of the complete article

Version history
  • Version 1 (August 1, 1980): No description
Advertisement
Advertisement