Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Pancreatic Cancer (Jul 2025)
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Abstract
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Rapid Publication Free access | 10.1172/JCI109150

Glucose Disposal during Insulinopenia in Somatostatin-Treated Dogs: THE ROLES OF GLUCOSE AND GLUCAGON

Gerald I. Shulman, John E. Liljenquist, Phillip E. Williams, William W. Lacy, and Alan D. Cherrington

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232

Department of Physiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232

Find articles by Shulman, G. in: PubMed | Google Scholar

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232

Department of Physiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232

Find articles by Liljenquist, J. in: PubMed | Google Scholar

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232

Department of Physiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232

Find articles by Williams, P. in: PubMed | Google Scholar

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232

Department of Physiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232

Find articles by Lacy, W. in: PubMed | Google Scholar

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232

Department of Physiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232

Find articles by Cherrington, A. in: PubMed | Google Scholar

Published August 1, 1978 - More info

Published in Volume 62, Issue 2 on August 1, 1978
J Clin Invest. 1978;62(2):487–491. https://doi.org/10.1172/JCI109150.
© 1978 The American Society for Clinical Investigation
Published August 1, 1978 - Version history
View PDF
Abstract

The first aim of this study was to determine whether the plasma glucose level can regulate hepatic glucose balance in vivo independent of its effects on insulin and glucagon secretion. To accomplish this, glucose was infused into conscious dogs whose basal insulin and glucagon secretion had been replaced by exogenous intraportal insulin and glucagon infusion after somatostatin inhibition of endogenous pancreatic hormone release. The acute induction of hyperglycemia (mean increment of 121 mg/dl) in the presence of basal levels of insulin (7±1 μU/ml) and glucagon (76±3 pg/ml) resulted in a 56% decrease in net hepatic glucose production but did not cause net hepatic glucose uptake.

The second aim of the study was to determine whether a decrease in the plasma glucagon level would modify the effect of glucose on the liver. The above protocol was repeated with the exception that glucagon was withdrawn (83% decrease in plasma glucagon) coincident with the induction of hyperglycemia. Under this circumstance, with the insulin level basal (7±1 μU/ml) and the glucagon levels reduced (16±2 pg/ml), hyperglycemia (mean increment of 130 mg/dl) promoted marked net hepatic glucose uptake (1.5±0.2 mg/kg per min) and glycogen deposition. In conclusion, (a) physiological increments in the plasma glucose concentration, independent of their effects on insulin and glucagon secretion, can significantly reduce net hepatic glucose production in vivo but at levels as high as 230 mg/dl cannot induce net hepatic glucose storage and (b) in the presence of basal insulin the ability of hyperglycemia to stimulate net hepatic glucose storage is influenced by the plasma glucagon concentration.

Browse pages

Click on an image below to see the page. View PDF of the complete article

icon of scanned page 487
page 487
icon of scanned page 488
page 488
icon of scanned page 489
page 489
icon of scanned page 490
page 490
icon of scanned page 491
page 491
Version history
  • Version 1 (August 1, 1978): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Abstract
  • Version history
Advertisement
Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts