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Treatment of insulin resistance with peroxisome proliferator–activated receptor γ agonists
Jerrold M. Olefsky
Jerrold M. Olefsky
Published August 15, 2000
Citation Information: J Clin Invest. 2000;106(4):467-472. https://doi.org/10.1172/JCI10843.
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Perspective

Treatment of insulin resistance with peroxisome proliferator–activated receptor γ agonists

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Abstract

Authors

Jerrold M. Olefsky

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Figure 2

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Selective PPAR modulator (SPPARM) model of PPARγ ligand action. Differen...
Selective PPAR modulator (SPPARM) model of PPARγ ligand action. Different PPARγ ligands (ligands 1, 2, and 3) bind to the ligand-binding domain of the PPARγ receptor. Each ligand receptor complex assumes a somewhat different three-dimensional conformation, leading to unique and differential interactions with cofactors, histones, other transcription factors, etc. As a result of these differential interactions, each PPARγ ligand receptor complex leads to a differential, but overlapping, pattern of gene expression. Thus, each ligand will activate, or repress, a certain set of genes, some of which are in common with other ligands, and some of which are not. Adapted from McDonnell (48).

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