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Obesity and insulin resistance
Barbara B. Kahn, Jeffrey S. Flier
Barbara B. Kahn, Jeffrey S. Flier
Published August 15, 2000
Citation Information: J Clin Invest. 2000;106(4):473-481. https://doi.org/10.1172/JCI10842.
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Perspective

Obesity and insulin resistance

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Abstract

Authors

Barbara B. Kahn, Jeffrey S. Flier

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Figure 3

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Leptin exerts multiple actions to regulate glucose homeostasis through a...
Leptin exerts multiple actions to regulate glucose homeostasis through autocrine, paracrine, endocrine, and neural circuits. Whereas many of leptin’s effects are mediated by the CNS, some effects may be exerted directly at the level of insulin target tissues or pancreatic islet cells.

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