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Obesity and insulin resistance
Barbara B. Kahn, Jeffrey S. Flier
Barbara B. Kahn, Jeffrey S. Flier
Published August 15, 2000
Citation Information: J Clin Invest. 2000;106(4):473-481. https://doi.org/10.1172/JCI10842.
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Perspective

Obesity and insulin resistance

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Abstract

Authors

Barbara B. Kahn, Jeffrey S. Flier

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Figure 1

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Pleiotropic effects of insulin to promote adipose storage. Insulin stimu...
Pleiotropic effects of insulin to promote adipose storage. Insulin stimulates differentiation of preadipocytes to adipocytes. In adipocytes, insulin promotes lipogenesis by stimulating the uptake of glucose and lipoprotein-derived fatty acids and by inducing ADD-1/SREBP-1c, which regulates genes promoting fatty acid synthesis and lipogenesis, not only in adipocytes but also in hepatocytes. Insulin may also regulate transcription through Forkhead transcription factors. Insulin diminishes triglyceride breakdown by inhibiting lipolysis. Many of these metabolic pathways are regulated by the PI3K signaling pathway.

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