Observations on the responsiveness of human subjects to human growth hormone: Effects of endogenous growth hormone deficiency and myotonic dystrophy

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Abstract

The effect of human growth hormone (HGH) on the N, P, Na, and K balance, and on the body weight (BW) of three groups of subjects was measured. In group I were nine cases (age 6-69) with HGH deficiency; in group II, eight cases (age 9-79) with normal endogenous HGH; in group III, four cases with myotonic dystrophy (age 45-51). After a 7 day control period, the hormone was administered for 7 days. Each subject was tested with three doses of HGH: dose A, 0.0168 U/kg BW3/4 per day; dose B, 0.0532 U/kg BW3/4 per day; dose C, 0.168 U/kg BW3/4 per day.

Authors

Daniel Rudman, Samuel B. Chyatte, Joseph H. Patterson, Glynda G. Gerron, Irma O'Beirne, Joan Barlow, Peter Ahmann, Ashby Jordan, Robert C. Mosteller