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Free access | 10.1172/JCI106392

Dihydrotestosterone in prostatic hypertrophy: II. The formation and content of dihydrotestosterone in the hypertrophic canine prostate and the effect of dihydrotestosterone on prostate growth in the dog

Robert E. Gloyna, Pentti K. Siiteri, and Jean D. Wilson

Department of Internal Medicine, The University of Texas Southwestern Medical School at Dallas, Dallas, Texas 75235

Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical School at Dallas, Dallas, Texas 75235

Department of Biochemistry, The University of Texas Southwestern Medical School at Dallas, Dallas, Texas 75235

Find articles by Gloyna, R. in: PubMed | Google Scholar

Department of Internal Medicine, The University of Texas Southwestern Medical School at Dallas, Dallas, Texas 75235

Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical School at Dallas, Dallas, Texas 75235

Department of Biochemistry, The University of Texas Southwestern Medical School at Dallas, Dallas, Texas 75235

Find articles by Siiteri, P. in: PubMed | Google Scholar

Department of Internal Medicine, The University of Texas Southwestern Medical School at Dallas, Dallas, Texas 75235

Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical School at Dallas, Dallas, Texas 75235

Department of Biochemistry, The University of Texas Southwestern Medical School at Dallas, Dallas, Texas 75235

Find articles by Wilson, J. in: PubMed | Google Scholar

Published September 1, 1970 - More info

Published in Volume 49, Issue 9 on September 1, 1970
J Clin Invest. 1970;49(9):1746–1753. https://doi.org/10.1172/JCI106392.
© 1970 The American Society for Clinical Investigation
Published September 1, 1970 - Version history
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Abstract

Three types of studies have been performed in immature, mature, and hypertrophic prostate glands of the dog. First, the concentrations of testosterone and dihydrotestosterone have been measured in the three types of gland. Dihydrotestosterone was the predominant hormone recovered in all prostates studied and was present in approximately five times higher concentration in the hypertrophic as compared to the other types of dog prostate. Second, pharmacological doses of dihydrotestosterone were administered to castrated dogs for 9 months and resulted in a distinct acceleration of prostatic growth as compared to testosterone treatment. Third, the rates of formation and degradation of dihydrotestosterone were measured in normal and hypertrophic tissue and were found to be essentially the same. These observations suggest that dihydrotestosterone accumulation may be causally linked to the development of canine prostatic hypertrophy. However, the mechanism by which dihydrotestosterone accumulates in the prostate remains to be determined.

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