Advertisement

Free access | 10.1172/JCI105914

Immunogenetics of human haptoglobins: I. The antigenic structure of normal Hp phenotypes

Jamshid Javid and Wendy Yingling

1Department of Medicine, New York University School of Medicine, New York 10016

Find articles by Javid, J. in: PubMed | Google Scholar

1Department of Medicine, New York University School of Medicine, New York 10016

Find articles by Yingling, W. in: PubMed | Google Scholar

Published October 1, 1968 - More info

Published in Volume 47, Issue 10 on October 1, 1968
J Clin Invest. 1968;47(10):2290–2296. https://doi.org/10.1172/JCI105914.
© 1968 The American Society for Clinical Investigation
Published October 1, 1968 - Version history
View PDF
Abstract

The various antigenic determinants of serum haptoglobins (Hp) may be studied semiquantitatively in a radioimmunoassay system. Using three antisera of overlapping specificities, we constructed an antigenic model of the various Hp phenotypes comprising four distinct determinants. This adds a new determinant, situated near the hemoglobin binding site, to the three determinants reported in the literature.

The assay system is sensitive to 0.2 μg or less of serum Hp. Furthermore, it can detect determinants that are not recognized by double diffusion studies.

Browse pages

Click on an image below to see the page. View PDF of the complete article

Version history
  • Version 1 (October 1, 1968): No description
Advertisement
Advertisement