Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Author's Takes
  • Reviews
    • View all reviews ...
    • Next-Generation Sequencing in Medicine (Upcoming)
    • New Therapeutic Targets in Cardiovascular Diseases (Mar 2022)
    • Immunometabolism (Jan 2022)
    • Circadian Rhythm (Oct 2021)
    • Gut-Brain Axis (Jul 2021)
    • Tumor Microenvironment (Mar 2021)
    • 100th Anniversary of Insulin's Discovery (Jan 2021)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Commentaries
    • Concise Communication
    • Editorials
    • Viewpoint
    • Top read articles
  • Clinical Medicine
  • JCI This Month
    • Current issue
    • Past issues

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Author's Takes
  • In-Press Preview
  • Commentaries
  • Concise Communication
  • Editorials
  • Viewpoint
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Alerts
  • Advertising
  • Job board
  • Subscribe
  • Contact
Top
  • View PDF
  • Download citation information
  • Send a comment
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal
  • Top
  • Abstract
  • Version history
  • Article usage
  • Citations to this article

Advertisement

Free access | 10.1172/JCI105854

The red cell mass-arterial oxygen relationship in normal man: Application to patients with chronic obstructive airway disease

John V. Weil, Gail Jamieson, Donald W. Brown, and Robert F. Grover

Cardiovascular Pulmonary Research and High Altitude Research Laboratories of the University of Colorado Medical Center, Denver, Colorado 80220

Find articles by Weil, J. in: JCI | PubMed | Google Scholar

Cardiovascular Pulmonary Research and High Altitude Research Laboratories of the University of Colorado Medical Center, Denver, Colorado 80220

Find articles by Jamieson, G. in: JCI | PubMed | Google Scholar

Cardiovascular Pulmonary Research and High Altitude Research Laboratories of the University of Colorado Medical Center, Denver, Colorado 80220

Find articles by Brown, D. in: JCI | PubMed | Google Scholar

Cardiovascular Pulmonary Research and High Altitude Research Laboratories of the University of Colorado Medical Center, Denver, Colorado 80220

Find articles by Grover, R. in: JCI | PubMed | Google Scholar

Published July 1, 1968 - More info

Published in Volume 47, Issue 7 on July 1, 1968
J Clin Invest. 1968;47(7):1627–1639. https://doi.org/10.1172/JCI105854.
© 1968 The American Society for Clinical Investigation
Published July 1, 1968 - Version history
View PDF
Abstract

The normal relationship between red cell mass measured, with 51chromium-labeled red cells, and arterial oxygen saturation (SaO2) over the range from 97.3 to 83.4% was examined by studying 73 normal men residing at sea level and altitudes of 1600 and 3100 m. A simple, linear relationship between SaO2 and red cell mass was found over the entire range (r = - 0.7524, P < 0.001). In contrast, a correlation between red cell mass and arterial O2 tension was found only over the lower half of the range of O2 tensions where SaO2 was also decreased (r = - 0.7731, P < 0.005). This suggested that O2 saturation rather than tension is the more important determinant of the erythropoietic response to chronic hypoxia. If this response is regulated by tissue O2 tension, then it will be influenced by O2 transport, which, in turn, is a function of blood flow and arterial O2 content, and hence SaO2. In nine patients with chronic obstructive airway disease the relationship between red cell mass and SaO2 was also determined and was found to be steeper than in the normal subjects (P < 0.05).

Images.

Browse pages

Click on an image below to see the page. View PDF of the complete article

icon of scanned page 1627
page 1627
icon of scanned page 1628
page 1628
icon of scanned page 1629
page 1629
icon of scanned page 1630
page 1630
icon of scanned page 1631
page 1631
icon of scanned page 1632
page 1632
icon of scanned page 1633
page 1633
icon of scanned page 1634
page 1634
icon of scanned page 1635
page 1635
icon of scanned page 1636
page 1636
icon of scanned page 1637
page 1637
icon of scanned page 1638
page 1638
icon of scanned page 1639
page 1639
Version history
  • Version 1 (July 1, 1968): No description

Article tools

  • View PDF
  • Download citation information
  • Send a comment
  • Share this article
  • Terms of use
  • Standard abbreviations
  • Need help? Email the journal

Metrics

  • Article usage
  • Citations to this article

Go to

  • Top
  • Abstract
  • Version history
Advertisement
Advertisement

Copyright © 2022 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts