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Signaling pathways in insulin action: molecular targets of insulin resistance
Jeffrey E. Pessin, Alan R. Saltiel
Jeffrey E. Pessin, Alan R. Saltiel
Published January 15, 2000
Citation Information: J Clin Invest. 2000;106(2):165-169. https://doi.org/10.1172/JCI10582.
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Perspective

Signaling pathways in insulin action: molecular targets of insulin resistance

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Abstract

Authors

Jeffrey E. Pessin, Alan R. Saltiel

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Figure 1

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Schematic model indicating the presence of two potential insulin recepto...
Schematic model indicating the presence of two potential insulin receptor–dependent signal transduction pathways. In this model, insulin stimulation results in the activation of a PI 3-kinase–dependent pathway that is necessary but not sufficient to induce GLUT4 translocation. In parallel, the insulin receptor activates an additional pathway leading to Cbl tyrosine phosphorylation through its interaction with the CAP protein. Syn4, syntaxin 4; PI3-K, PI 3-kinase.

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