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Immune recognition of OxLDL in atherosclerosis
John F. Kearney
John F. Kearney
Published June 15, 2000
Citation Information: J Clin Invest. 2000;105(12):1683-1685. https://doi.org/10.1172/JCI10426.
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Commentary

Immune recognition of OxLDL in atherosclerosis

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Abstract

Authors

John F. Kearney

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Figure 1

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Potential role of OxLDL and ApoE in autoantibody production. Top: Under ...
Potential role of OxLDL and ApoE in autoantibody production. Top: Under normal circumstances, the newly formed IgM+ B-cell population in the perinatal bone marrow or fetal liver can respond to millions of specific antigenic structures. Included in this population are anti-PC clones, some of which carry the T15 idiotype. In the selection step, PC epitopes on apoptotic material or OxLDL (selecting Ag) may enrich for T15/PC-specific B cells. The degree to which this occurs would be limited by the efficiency of debris-scavenging by macrophages or by the availability of ApoE. Additionally, these T15 clones may be stimulated to differentiate by the normally regulated amounts of PC or OxLDL (activating Ag). Bottom: In the absence of ApoE, accumulated OxLDL may promote a still more profound enrichment for T15 clones or may stimulate existing clones to differentiate into T15-producing (natural antibody–producing) plasma cells. Either possibility would give rise to the high levels of anti-OxLDL antibodies observed in the ApoE–/– mice. Circles represent B cells; ovals represent mature antibody-secreting plasma cells. Blue, αPC; yellow, T15/PC.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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