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Evidence for angiotensin II type 2 receptor–mediated cardiac myocyte enlargement during in vivo pressure overload
Takaaki Senbonmatsu, … , F. Andrew Gaffney, Tadashi Inagami
Takaaki Senbonmatsu, … , F. Andrew Gaffney, Tadashi Inagami
Published August 1, 2000
Citation Information: J Clin Invest. 2000;106(3):R25-R29. https://doi.org/10.1172/JCI10037.
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Evidence for angiotensin II type 2 receptor–mediated cardiac myocyte enlargement during in vivo pressure overload

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Abstract

The pathophysiological roles of the angiotensin II type 2 receptor (AT2) in cardiac hypertrophy remain unclear. By the targeted deletion of mouse AT2 we were able to prevent the left ventricular hypertrophy resulting from pressure overload, while cardiac contractile functions remained normal. This implies that AT2 is a mediator of cardiac hypertrophy in response to increased blood pressure. The effects of AT2 deletion were independent of activation of embryonic genes for cardiac hypertrophy. However, p70S6k, one of the key factors in cardiac hypertrophy, was markedly and specifically reduced in the ventricles of Agtr2–/Y mice. We propose that p70S6k plays a major role in AT2-mediated ventricular hypertrophy.

Authors

Takaaki Senbonmatsu, Sahoko Ichihara, Edward Price Jr., F. Andrew Gaffney, Tadashi Inagami

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Figure 1

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(a) Systolic blood pressure in Agtr2–/Y and wild-type mice. Filled circl...
(a) Systolic blood pressure in Agtr2–/Y and wild-type mice. Filled circles: aortic-banded Agtr2–/Y mice; filled squares: aortic-banded wild-type mice; open circles: sham-operated Agtr2–/Y mice; open squares: sham-operated wild-type mice. AP < 0.05. (b) IVS and LVPW in aortic-banded Agtr2–/Y and wild-type mice. Filled circles: IVS in aortic-banded Agtr2–/Y mice; filled squares: IVS in aortic-banded wild-type mice; open circles: LVPW in aortic-banded Agtr2–/Y mice; open squares: LVPW in aortic-banded wild-type mice. AP < 0.05. (c) LVM of Agtr2–/Y and wild-type mice. Filled circles: aortic-banded Agtr2–/Y mice; open circles: sham-operated Agtr2–/Y mice; filled squares: aortic-banded wild-type mice; open squares: sham-operated wild-type mice. AP < 0.05.

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ISSN: 0021-9738 (print), 1558-8238 (online)

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