Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Clinical innovation and scientific progress in GLP-1 medicine (Nov 2025)
    • Pancreatic Cancer (Jul 2025)
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Issue published October 15, 2002 Previous issue | Next issue

  • Volume 110, Issue 8
Go to section:
  • In this issue
  • Science and Society
  • Perspective
  • Commentaries
  • Research Articles
  • Erratum
  • Corrigendum
In this issue
In This Issue
View: Text | PDF

In This Issue

  • Text
  • PDF
Abstract

Authors

×
Science and Society
It takes a village to raise an idiot: fixing US science education
Alan Dove
Alan Dove
View: Text | PDF

It takes a village to raise an idiot: fixing US science education

  • Text
  • PDF
Abstract

Science and Society

Authors

Alan Dove

×
Perspective
Bacterial infectious disease control by vaccine development
Roy Curtiss III
Roy Curtiss III
View: Text | PDF

Bacterial infectious disease control by vaccine development

  • Text
  • PDF
Abstract

Perspective

Authors

Roy Curtiss III

×
Commentaries
Does loss of bile acid homeostasis make mice melancholy?
David D. Moore
David D. Moore
View: Text | PDF

Does loss of bile acid homeostasis make mice melancholy?

  • Text
  • PDF
Abstract

Commentary

Authors

David D. Moore

×

Genome-wide responses of a pathogenic bacterium to its host
David A. Relman
David A. Relman
View: Text | PDF

Genome-wide responses of a pathogenic bacterium to its host

  • Text
  • PDF
Abstract

Commentary

Authors

David A. Relman

×

Defective cardiac ion channels: from mutations to clinical syndromes
Colleen E. Clancy, Robert S. Kass
Colleen E. Clancy, Robert S. Kass
View: Text | PDF

Defective cardiac ion channels: from mutations to clinical syndromes

  • Text
  • PDF
Abstract

Commentary

Authors

Colleen E. Clancy, Robert S. Kass

×

Intestinal attraction: CCL25 functions in effector lymphocyte recruitment to the small intestine
Daniel J. Campbell, Eugene C. Butcher
Daniel J. Campbell, Eugene C. Butcher
View: Text | PDF

Intestinal attraction: CCL25 functions in effector lymphocyte recruitment to the small intestine

  • Text
  • PDF
Abstract

Commentary

Authors

Daniel J. Campbell, Eugene C. Butcher

×
Research Articles
Neutrophil-independent mechanisms of caspase-1– and IL-18–mediated ischemic acute tubular necrosis in mice
Vyacheslav Y. Melnikov, Sarah Faubel, Britta Siegmund, M. Scott Lucia, Danica Ljubanovic, Charles L. Edelstein
Vyacheslav Y. Melnikov, Sarah Faubel, Britta Siegmund, M. Scott Lucia, Danica Ljubanovic, Charles L. Edelstein
View: Text | PDF

Neutrophil-independent mechanisms of caspase-1– and IL-18–mediated ischemic acute tubular necrosis in mice

  • Text
  • PDF
Abstract

Research Article

Authors

Vyacheslav Y. Melnikov, Sarah Faubel, Britta Siegmund, M. Scott Lucia, Danica Ljubanovic, Charles L. Edelstein

×

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
I. Sadaf Farooqi, Giuseppe Matarese, Graham M. Lord, Julia M. Keogh, Elizabeth Lawrence, Chizo Agwu, Veronica Sanna, Susan A. Jebb, Francesco Perna, Silvia Fontana, Robert I. Lechler, Alex M. DePaoli, Stephen O’Rahilly
I. Sadaf Farooqi, Giuseppe Matarese, Graham M. Lord, Julia M. Keogh, Elizabeth Lawrence, Chizo Agwu, Veronica Sanna, Susan A. Jebb, Francesco Perna, Silvia Fontana, Robert I. Lechler, Alex M. DePaoli, Stephen O’Rahilly
View: Text | PDF

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency

  • Text
  • PDF
Abstract

Research Article

Authors

I. Sadaf Farooqi, Giuseppe Matarese, Graham M. Lord, Julia M. Keogh, Elizabeth Lawrence, Chizo Agwu, Veronica Sanna, Susan A. Jebb, Francesco Perna, Silvia Fontana, Robert I. Lechler, Alex M. DePaoli, Stephen O’Rahilly

×

Role of matrix metalloproteinase-9 in angiogenesis caused by ocular infection with herpes simplex virus
Sujin Lee, Mei Zheng, Bumseok Kim, Barry T. Rouse
Sujin Lee, Mei Zheng, Bumseok Kim, Barry T. Rouse
View: Text | PDF

Role of matrix metalloproteinase-9 in angiogenesis caused by ocular infection with herpes simplex virus

  • Text
  • PDF
Abstract

Research Article

Authors

Sujin Lee, Mei Zheng, Bumseok Kim, Barry T. Rouse

×

CCL25 mediates the localization of recently activated CD8αβ+ lymphocytes to the small-intestinal mucosa
Marcus Svensson, Jan Marsal, Anna Ericsson, Laura Carramolino, Therese Brodén, Gabriel Márquez, William W. Agace
Marcus Svensson, Jan Marsal, Anna Ericsson, Laura Carramolino, Therese Brodén, Gabriel Márquez, William W. Agace
View: Text | PDF

CCL25 mediates the localization of recently activated CD8αβ+ lymphocytes to the small-intestinal mucosa

  • Text
  • PDF
Abstract

Research Article

Authors

Marcus Svensson, Jan Marsal, Anna Ericsson, Laura Carramolino, Therese Brodén, Gabriel Márquez, William W. Agace

×

Benzodiazepine-induced superoxide signalsB cell apoptosis: mechanistic insight and potential therapeutic utility
Neal B. Blatt, Jeffrey J. Bednarski, Roscoe E. Warner, Francesco Leonetti, Kathryn M. Johnson, Anthony Boitano, Raymond Yung, Bruce C. Richardson, Kent J. Johnson, Jonathan A. Ellman, Anthony W. Opipari Jr., Gary D. Glick
Neal B. Blatt, Jeffrey J. Bednarski, Roscoe E. Warner, Francesco Leonetti, Kathryn M. Johnson, Anthony Boitano, Raymond Yung, Bruce C. Richardson, Kent J. Johnson, Jonathan A. Ellman, Anthony W. Opipari Jr., Gary D. Glick
View: Text | PDF

Benzodiazepine-induced superoxide signalsB cell apoptosis: mechanistic insight and potential therapeutic utility

  • Text
  • PDF
Abstract

Research Article

Authors

Neal B. Blatt, Jeffrey J. Bednarski, Roscoe E. Warner, Francesco Leonetti, Kathryn M. Johnson, Anthony Boitano, Raymond Yung, Bruce C. Richardson, Kent J. Johnson, Jonathan A. Ellman, Anthony W. Opipari Jr., Gary D. Glick

×

Collagen deposition in HIV-1 infected lymphatic tissues and T cell homeostasis
Timothy W. Schacker, Phuong L. Nguyen, Gregory J. Beilman, Steven Wolinsky, Matthew Larson, Cavan Reilly, Ashley T. Haase
Timothy W. Schacker, Phuong L. Nguyen, Gregory J. Beilman, Steven Wolinsky, Matthew Larson, Cavan Reilly, Ashley T. Haase
View: Text | PDF

Collagen deposition in HIV-1 infected lymphatic tissues and T cell homeostasis

  • Text
  • PDF
Abstract

Research Article

Authors

Timothy W. Schacker, Phuong L. Nguyen, Gregory J. Beilman, Steven Wolinsky, Matthew Larson, Cavan Reilly, Ashley T. Haase

×

EphB6 crosslinking results in costimulation of T cells
Hongyu Luo, Guang Yu, Yulian Wu, Jiangping Wu
Hongyu Luo, Guang Yu, Yulian Wu, Jiangping Wu
View: Text | PDF

EphB6 crosslinking results in costimulation of T cells

  • Text
  • PDF
Abstract

Research Article

Authors

Hongyu Luo, Guang Yu, Yulian Wu, Jiangping Wu

×

mRNA expression profiles for Escherichia coli ingested by normal and phagocyte oxidase-deficient human neutrophils
Benjamin J. Staudinger, Michele A. Oberdoerster, Patrick J. Lewis, Henry Rosen
Benjamin J. Staudinger, Michele A. Oberdoerster, Patrick J. Lewis, Henry Rosen
View: Text | PDF

mRNA expression profiles for Escherichia coli ingested by normal and phagocyte oxidase-deficient human neutrophils

  • Text
  • PDF
Abstract

Research Article

Authors

Benjamin J. Staudinger, Michele A. Oberdoerster, Patrick J. Lewis, Henry Rosen

×

Delta-1 enhances marrow and thymus repopulating ability of human CD34+CD38– cord blood cells
Kohshi Ohishi, Barbara Varnum-Finney, Irwin D. Bernstein
Kohshi Ohishi, Barbara Varnum-Finney, Irwin D. Bernstein
View: Text | PDF

Delta-1 enhances marrow and thymus repopulating ability of human CD34+CD38– cord blood cells

  • Text
  • PDF
Abstract

Research Article

Authors

Kohshi Ohishi, Barbara Varnum-Finney, Irwin D. Bernstein

×

Noncoding RNA danger motifs bridge innate and adaptive immunity and are potent adjuvants for vaccination
Lilin Wang, Dan Smith, Simona Bot, Luis Dellamary, Amy Bloom, Adrian Bot
Lilin Wang, Dan Smith, Simona Bot, Luis Dellamary, Amy Bloom, Adrian Bot
View: Text | PDF

Noncoding RNA danger motifs bridge innate and adaptive immunity and are potent adjuvants for vaccination

  • Text
  • PDF
Abstract

Research Article

Authors

Lilin Wang, Dan Smith, Simona Bot, Luis Dellamary, Amy Bloom, Adrian Bot

×

Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors
Shinya Ugawa, Takashi Ueda, Yusuke Ishida, Makoto Nishigaki, Yasuhiro Shibata, Shoichi Shimada
Shinya Ugawa, Takashi Ueda, Yusuke Ishida, Makoto Nishigaki, Yasuhiro Shibata, Shoichi Shimada
View: Text | PDF

Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors

  • Text
  • PDF
Abstract

Research Article

Authors

Shinya Ugawa, Takashi Ueda, Yusuke Ishida, Makoto Nishigaki, Yasuhiro Shibata, Shoichi Shimada

×

Cholic acid mediates negative feedback regulation of bile acid synthesis in mice
Jia Li-Hawkins, Mats Gåfvels, Maria Olin, Erik G. Lund, Ulla Andersson, Gertrud Schuster, Ingemar Björkhem, David W. Russell, Gosta Eggertsen
Jia Li-Hawkins, Mats Gåfvels, Maria Olin, Erik G. Lund, Ulla Andersson, Gertrud Schuster, Ingemar Björkhem, David W. Russell, Gosta Eggertsen
View: Text | PDF

Cholic acid mediates negative feedback regulation of bile acid synthesis in mice

  • Text
  • PDF
Abstract

Research Article

Authors

Jia Li-Hawkins, Mats Gåfvels, Maria Olin, Erik G. Lund, Ulla Andersson, Gertrud Schuster, Ingemar Björkhem, David W. Russell, Gosta Eggertsen

×

Long QT syndrome, Brugada syndrome, and conduction system disease are linked to a single sodium channel mutation
Augustus O. Grant, Michael P. Carboni, Valentina Neplioueva, C. Frank Starmer, Mirella Memmi, Carlo Napolitano, Silvia Priori
Augustus O. Grant, Michael P. Carboni, Valentina Neplioueva, C. Frank Starmer, Mirella Memmi, Carlo Napolitano, Silvia Priori
View: Text | PDF

Long QT syndrome, Brugada syndrome, and conduction system disease are linked to a single sodium channel mutation

  • Text
  • PDF
Abstract

Research Article

Authors

Augustus O. Grant, Michael P. Carboni, Valentina Neplioueva, C. Frank Starmer, Mirella Memmi, Carlo Napolitano, Silvia Priori

×
Erratum
Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome
Duarte C. Barral, José S. Ramalho, Ross Anders, Alistair N. Hume, Holly J. Knapton, Tanya Tolmachova, Lucy M. Collinson, David Goulding, Kalwant S. Authi, Miguel C. Seabra
Duarte C. Barral, José S. Ramalho, Ross Anders, Alistair N. Hume, Holly J. Knapton, Tanya Tolmachova, Lucy M. Collinson, David Goulding, Kalwant S. Authi, Miguel C. Seabra
View: Text | PDF | Amended Article

Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome

  • Text
  • PDF
Abstract

Erratum

Authors

Duarte C. Barral, José S. Ramalho, Ross Anders, Alistair N. Hume, Holly J. Knapton, Tanya Tolmachova, Lucy M. Collinson, David Goulding, Kalwant S. Authi, Miguel C. Seabra

×
Corrigendum
Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair
Xinping Zhang, Edward M. Schwarz, Donald A. Young, J. Edward Puzas, Randy N. Rosier, Regis J. O’Keefe
Xinping Zhang, Edward M. Schwarz, Donald A. Young, J. Edward Puzas, Randy N. Rosier, Regis J. O’Keefe
View: Text | PDF | Amended Article

Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair

  • Text
  • PDF
Abstract

Corrigendum

Authors

Xinping Zhang, Edward M. Schwarz, Donald A. Young, J. Edward Puzas, Randy N. Rosier, Regis J. O’Keefe

×
Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts