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Cover story: Managing miscreant microbes
False colored SEM showing the microbes E. coli (yellow), Staphylococcus aureus (peach), and Streptococcus pneumoniae (purple). This month’s issue features articles highlighting aspects of microbe management. Zhang et al. characterize the TLR2-, IL-17A–, and CD4+ T cell–dependent recruitment of cellular effectors that control the clearance of mucosal pneumococcal colonization (page 1899). Shahangian et al. also investigate pneumococci, but focus on type I IFN signaling after influenza infection (page 1910). Martin et al. show that type I IFN are also important in S. aureus infection (page 1931). Andonegui and colleagues show that TLR4 on the endothelium is the primary intravascular sentinel for detection of bacteria such as E. coli (page 1921).
Also inside:
Intermediate filaments (IFs) are one of the three major fibrillar cytoplasmic elements that make up the cytoskeleton. Cytoskeletal IFs in distinct cell types are formed from different members of a large family of proteins, the IF protein family, which also includes proteins that are present in the nucleus, where they are the main component of the nucleoskeleton. As discussed in this Review series, roles have been revealed for IFs in more than 80 human tissue-specific diseases.
Rethinking Mental Disorders
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CSF-1 signals directly to renal tubular epithelial cells to mediate repair in mice
Focal adhesion kinase is required for neural crest cell morphogenesis during mouse cardiovascular development
The TLR9-MyD88 pathway is critical for adaptive immune responses to adeno-associated virus gene therapy vectors in mice
The circadian clock protein Period 1 regulates expression of the renal epithelial sodium channel in mice