Cover story: Managing miscreant microbes
False colored SEM showing the microbes E. coli (yellow), Staphylococcus aureus (peach), and Streptococcus pneumoniae (purple). This month’s issue features articles highlighting aspects of microbe management. Zhang et al. characterize the TLR2-, IL-17A–, and CD4⁺ T cell–dependent recruitment of cellular effectors that control the clearance of mucosal pneumococcal colonization (page 1899). Shahangian et al. also investigate pneumococci, but focus on type I IFN signaling after influenza infection (page 1910). Martin et al. show that type I IFN are also important in S. aureus infection (page 1931). Andonegui and colleagues show that TLR4 on the endothelium is the primary intravascular sentinel for detection of bacteria such as E. coli (page 1921).