Cover story: Renal failure in multiple myeloma
A common renal complication of multiple myeloma is cast nephropathy, which results from the co-precipitate of monoclonal immunoglobulin free light chains (FLC) with Tamm-Horsfall glycoproteins (THP) in the lumen of the distal nephron. In this issue, Ying and colleagues describe a cyclized competitor peptide that inhibits the binding of FLC to THP (page 1777) and could represent an approach to the management of renal failure during multiple myeloma.
Image credit: Shutterstock, Inc. Copyright: Denis Barbulat.

Three of medicine’s most charismatic giants (Robert Lefkowitz, Joseph Goldstein and Michael Brown) interview each other. Lefkowitz (Duke University) is known for his seminal discoveries in understanding G protein-coupled receptor function. The legendary partnership between Brown and Goldstein (University of Texas, Southwestern Medical Center) has spanned four decades. Together they were awarded the 1985 Nobel Prize in Physiology or Medicine acknowledging their discovery of the LDL cholesterol receptor and its role in the regulation of cholesterol metabolism. Together, they talk about their beginnings in science, where they got their scientific inspiration, how to be a good mentor, and how to deal with scientific celebrity.

Previously: Harold E. Varmus