Cover story: Taming tumor hypoxia and metabolism
Human tumor cells stained for DAPI (blue), cytochrome c (red), and CHCHD4 (green). The HIF pathway plays a central role in sensing and responding to changes in cellular oxygen levels, and, since increased expression of HIF-α is observed in many human cancers, understanding how HIF-α becomes deregulated in cancer could lead to new therapeutic strategies. In their manuscript, Yang and colleagues (page 600) provide a novel mitochondrial link to hypoxia signaling. They identify and characterize a role for the CHCHD4 mitochondrial proteins in regulating HIF-α signaling, angiogenesis, and tumor progression.