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Cover story: Infiltrating the islet
Type I diabetes is caused when the body’s immune system attacks and destroys insulin-producing β cells within pancreatic islets. Cytotoxic T lymphocytes (CTLs) are thought to play the predominant role in destroying β cells. Coppieters and colleagues have now used intravital imaging to visualize the CTL-mediated killing of β cells in diabetic mice (page 119). Their observations indicate that diabetogenic CTLs move in a random manner and kill β cells at a relatively
slow rate.
Also inside:
Sexually transmitted infections (STIs) are major health problems worldwide, and despite identification of the causative agents and understanding of the mechanism of transmission, many have continued to grow in prevalence. Untreated, STIs may complicate pregnancy and fertility, lead to stillbirth, or result in chronic disease or death. Decades of research have offered glimpses into the pathophysiology of many of these diseases, but as the reviews in this series make clear, a deeper understanding of the natural history of infection, the molecular biology of the agents, and the environment of the hosts they invade will be necessary to achieve their control and eradication.
Cover image credit: Thomas Quinn
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