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Filtration barriers
The kidney is responsible for retaining essential proteins and removing waste products from the blood stream. The kidney filter is maintained by an intricate structure formed by the actin-rich...
Published November 15, 2013
Scientific Show Stopper
Protecting the kidney through ion channel inhibition
Damage to the glomerulus, which mediates the kidney's filtering function, causes plasma protein to spill into the urine, a sign of kidney failure and cardiovascular disease. Calcium influx into the podocytes, the cells that form the filtration b...
Published November 15, 2013
Author's Take
Exploring long-term expression of therapeutic transgenes
Results from early-phase clinical trials have indicated that recombinant adeno-associated viruses (rAAV) could potentially be used for gene therapy. In each trial, however, patients have developed T cell-mediated immune responses that may interfere ...
Published November 15, 2013
Author's Take
Maintaining the neuromuscular junction
Patients suffering from myasthenia gravis (MG) have debilitating muscle weakness and fatigue. MG is the result of neuromuscular junction (NMJ) dysfunction ...
Published November 8, 2013
Scientific Show Stopper
Germinal center control
The ability of the immune system to fend off specific pathogens following immunization depends the generation high-affinity antibody producing plasma cells (PCs) and long-lived memory B cells....
Published November 8, 2013
Scientific Show Stopper
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