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Thomas Südhof
The simple fact that you can understand the words on this page, and that you might remember any of this interview tomorrow, is thanks to the simultaneous and precise coordination of communication between the billions of neurons in your brain and per...
Published December 3, 2013
Conversations with Giants in Medicine
Maintaining T cell polyfunctionality
In order to protect the body from viruses and cancer, T cells must perform multiple functions, a feature that is often lost during chronic infection. Jonathan Schneck and colleagues examined the molecular mechanisms that maintain T cell polyfunction...
Published December 2, 2013
Author's Take
Looking through the fog
PTEN hamartoma syndrome (PHTS) is a diverse syndrome that develops as the result of mutations in the gene encoding the tumor suppressor PTEN. Cataract formation is common in PHTS patients;...
Published November 25, 2013
Scientific Show Stopper
Filtration barriers
The kidney is responsible for retaining essential proteins and removing waste products from the blood stream. The kidney filter is maintained by an intricate structure formed by the actin-rich...
Published November 15, 2013
Scientific Show Stopper
Protecting the kidney through ion channel inhibition
Damage to the glomerulus, which mediates the kidney's filtering function, causes plasma protein to spill into the urine, a sign of kidney failure and cardiovascular disease. Calcium influx into the podocytes, the cells that form the filtration b...
Published November 15, 2013
Author's Take
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