Go to JCI Insight
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact
  • Clinical Research and Public Health
  • Current issue
  • Past issues
  • By specialty
    • COVID-19
    • Cardiology
    • Gastroenterology
    • Immunology
    • Metabolism
    • Nephrology
    • Neuroscience
    • Oncology
    • Pulmonology
    • Vascular biology
    • All ...
  • Videos
    • Conversations with Giants in Medicine
    • Video Abstracts
  • Reviews
    • View all reviews ...
    • Complement Biology and Therapeutics (May 2025)
    • Evolving insights into MASLD and MASH pathogenesis and treatment (Apr 2025)
    • Microbiome in Health and Disease (Feb 2025)
    • Substance Use Disorders (Oct 2024)
    • Clonal Hematopoiesis (Oct 2024)
    • Sex Differences in Medicine (Sep 2024)
    • Vascular Malformations (Apr 2024)
    • View all review series ...
  • Viewpoint
  • Collections
    • In-Press Preview
    • Clinical Research and Public Health
    • Research Letters
    • Letters to the Editor
    • Editorials
    • Commentaries
    • Editor's notes
    • Reviews
    • Viewpoints
    • 100th anniversary
    • Top read articles

  • Current issue
  • Past issues
  • Specialties
  • Reviews
  • Review series
  • Conversations with Giants in Medicine
  • Video Abstracts
  • In-Press Preview
  • Clinical Research and Public Health
  • Research Letters
  • Letters to the Editor
  • Editorials
  • Commentaries
  • Editor's notes
  • Reviews
  • Viewpoints
  • 100th anniversary
  • Top read articles
  • About
  • Editors
  • Consulting Editors
  • For authors
  • Publication ethics
  • Publication alerts by email
  • Advertising
  • Job board
  • Contact

Issue published November 1, 1997 Previous issue | Next issue

  • Volume 100, Issue 9
Go to section:
  • Editorial
  • Perspectives
  • Research Articles
Editorial
Atherosclerosis, just another cancer?
S D Markowitz
S D Markowitz
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2143-2145. https://doi.org/10.1172/JCI119749.
View: Text | PDF

Atherosclerosis, just another cancer?

  • Text
  • PDF
Abstract

Editorial

Authors

S D Markowitz

×
Perspectives
Nitric oxide synthases: which, where, how, and why?
T Michel, O Feron
T Michel, O Feron
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2146-2152. https://doi.org/10.1172/JCI119750.
View: Text | PDF

Nitric oxide synthases: which, where, how, and why?

  • Text
  • PDF
Abstract

Perspective

Authors

T Michel, O Feron

×

Cellular and molecular mechanisms of endothelial cell dysfunction.
D G Harrison
D G Harrison
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2153-2157. https://doi.org/10.1172/JCI119751.
View: Text | PDF

Cellular and molecular mechanisms of endothelial cell dysfunction.

  • Text
  • PDF
Abstract

Perspective

Authors

D G Harrison

×
Research Articles
Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk.
F Folli, … , J L Bouchie, E P Feener
F Folli, … , J L Bouchie, E P Feener
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2158-2169. https://doi.org/10.1172/JCI119752.
View: Text | PDF

Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk.

  • Text
  • PDF
Abstract

Research Article

Authors

F Folli, C R Kahn, H Hansen, J L Bouchie, E P Feener

×

The atherogenic lipoprotein Lp(a) is internalized and degraded in a process mediated by the VLDL receptor.
K M Argraves, … , P C Harpel, D K Strickland
K M Argraves, … , P C Harpel, D K Strickland
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2170-2181. https://doi.org/10.1172/JCI119753.
View: Text | PDF

The atherogenic lipoprotein Lp(a) is internalized and degraded in a process mediated by the VLDL receptor.

  • Text
  • PDF
Abstract

Research Article

Authors

K M Argraves, K F Kozarsky, J T Fallon, P C Harpel, D K Strickland

×

Genomic instability in the type II TGF-beta1 receptor gene in atherosclerotic and restenotic vascular cells.
T A McCaffrey, … , G Bergman, H L Bush Jr
T A McCaffrey, … , G Bergman, H L Bush Jr
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2182-2188. https://doi.org/10.1172/JCI119754.
View: Text | PDF

Genomic instability in the type II TGF-beta1 receptor gene in atherosclerotic and restenotic vascular cells.

  • Text
  • PDF
Abstract

Research Article

Authors

T A McCaffrey, B Du, S Consigli, P Szabo, P J Bray, L Hartner, B B Weksler, T A Sanborn, G Bergman, H L Bush Jr

×

Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates.
J C Bowman, … , G I Fishman, P M Buttrick
J C Bowman, … , G I Fishman, P M Buttrick
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2189-2195. https://doi.org/10.1172/JCI119755.
View: Text | PDF

Expression of protein kinase C beta in the heart causes hypertrophy in adult mice and sudden death in neonates.

  • Text
  • PDF
Abstract

Research Article

Authors

J C Bowman, S F Steinberg, T Jiang, D L Geenen, G I Fishman, P M Buttrick

×

Abnormal sulfate metabolism in vitamin D-deficient rats.
I Fernandes, … , G Friedlander, C Silve
I Fernandes, … , G Friedlander, C Silve
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2196-2203. https://doi.org/10.1172/JCI119756.
View: Text | PDF

Abnormal sulfate metabolism in vitamin D-deficient rats.

  • Text
  • PDF
Abstract

Research Article

Authors

I Fernandes, G Hampson, X Cahours, P Morin, C Coureau, S Couette, D Prie, J Biber, H Murer, G Friedlander, C Silve

×

Disruption of the splicing enhancer sequence within exon 27 of the dystrophin gene by a nonsense mutation induces partial skipping of the exon and is responsible for Becker muscular dystrophy.
N Shiga, … , M Yokoyama, M Matsuo
N Shiga, … , M Yokoyama, M Matsuo
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2204-2210. https://doi.org/10.1172/JCI119757.
View: Text | PDF

Disruption of the splicing enhancer sequence within exon 27 of the dystrophin gene by a nonsense mutation induces partial skipping of the exon and is responsible for Becker muscular dystrophy.

  • Text
  • PDF
Abstract

Research Article

Authors

N Shiga, Y Takeshima, H Sakamoto, K Inoue, Y Yokota, M Yokoyama, M Matsuo

×

Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression.
U Dirksen, … , R Murray, S Burdach
U Dirksen, … , R Murray, S Burdach
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2211-2217. https://doi.org/10.1172/JCI119758.
View: Text | PDF

Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression.

  • Text
  • PDF
Abstract

Research Article

Authors

U Dirksen, R Nishinakamura, P Groneck, U Hattenhorst, L Nogee, R Murray, S Burdach

×

Phase I trial of recombinant adenovirus gene transfer in lung cancer. Longitudinal study of the immune responses to transgene and viral products.
H Gahéry-Ségard, … , J G Guillet, F Farace
H Gahéry-Ségard, … , J G Guillet, F Farace
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2218-2226. https://doi.org/10.1172/JCI119759.
View: Text | PDF

Phase I trial of recombinant adenovirus gene transfer in lung cancer. Longitudinal study of the immune responses to transgene and viral products.

  • Text
  • PDF
Abstract

Research Article

Authors

H Gahéry-Ségard, V Molinier-Frenkel, C Le Boulaire, P Saulnier, P Opolon, R Lengagne, E Gautier, A Le Cesne, L Zitvogel, A Venet, C Schatz, M Courtney, T Le Chevalier, T Tursz, J G Guillet, F Farace

×

HLA-DQB1 polymorphism determines incidence, onset, and severity of collagen-induced arthritis in transgenic mice. Implications in human rheumatoid arthritis.
D S Bradley, … , H S Luthra, C S David
D S Bradley, … , H S Luthra, C S David
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2227-2234. https://doi.org/10.1172/JCI119760.
View: Text | PDF | Correction

HLA-DQB1 polymorphism determines incidence, onset, and severity of collagen-induced arthritis in transgenic mice. Implications in human rheumatoid arthritis.

  • Text
  • PDF
Abstract

Research Article

Authors

D S Bradley, G H Nabozny, S Cheng, P Zhou, M M Griffiths, H S Luthra, C S David

×

Macula densa arginine delivery and uptake in the rat regulates glomerular capillary pressure. Effects of salt intake.
W J Welch, C S Wilcox
W J Welch, C S Wilcox
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2235-2242. https://doi.org/10.1172/JCI119761.
View: Text | PDF

Macula densa arginine delivery and uptake in the rat regulates glomerular capillary pressure. Effects of salt intake.

  • Text
  • PDF
Abstract

Research Article

Authors

W J Welch, C S Wilcox

×

Neonatal activation of CD28 signaling overcomes T cell anergy and prevents autoimmune diabetes by an IL-4-dependent mechanism.
G A Arreaza, … , B Singh, T L Delovitch
G A Arreaza, … , B Singh, T L Delovitch
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2243-2253. https://doi.org/10.1172/JCI119762.
View: Text | PDF

Neonatal activation of CD28 signaling overcomes T cell anergy and prevents autoimmune diabetes by an IL-4-dependent mechanism.

  • Text
  • PDF
Abstract

Research Article

Authors

G A Arreaza, M J Cameron, A Jaramillo, B M Gill, D Hardy, K B Laupland, M J Rapoport, P Zucker, S Chakrabarti, S W Chensue, H Y Qin, B Singh, T L Delovitch

×

Pretreatment with antibody to eosinophil major basic protein prevents hyperresponsiveness by protecting neuronal M2 muscarinic receptors in antigen-challenged guinea pigs.
C M Evans, … , G J Gleich, R W Costello
C M Evans, … , G J Gleich, R W Costello
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2254-2262. https://doi.org/10.1172/JCI119763.
View: Text | PDF

Pretreatment with antibody to eosinophil major basic protein prevents hyperresponsiveness by protecting neuronal M2 muscarinic receptors in antigen-challenged guinea pigs.

  • Text
  • PDF
Abstract

Research Article

Authors

C M Evans, A D Fryer, D B Jacoby, G J Gleich, R W Costello

×

Susceptibility to anti-glomerular basement membrane disease and Goodpasture syndrome is linked to MHC class II genes and the emergence of T cell-mediated immunity in mice.
R Kalluri, … , H Okada, E G Neilson
R Kalluri, … , H Okada, E G Neilson
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2263-2275. https://doi.org/10.1172/JCI119764.
View: Text | PDF

Susceptibility to anti-glomerular basement membrane disease and Goodpasture syndrome is linked to MHC class II genes and the emergence of T cell-mediated immunity in mice.

  • Text
  • PDF
Abstract

Research Article

Authors

R Kalluri, T M Danoff, H Okada, E G Neilson

×

Tissue factor expression in human arterial smooth muscle cells. TF is present in three cellular pools after growth factor stimulation.
A D Schecter, … , Y Nemerson, M B Taubman
A D Schecter, … , Y Nemerson, M B Taubman
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2276-2285. https://doi.org/10.1172/JCI119765.
View: Text | PDF

Tissue factor expression in human arterial smooth muscle cells. TF is present in three cellular pools after growth factor stimulation.

  • Text
  • PDF
Abstract

Research Article

Authors

A D Schecter, P L Giesen, O Taby, C L Rosenfield, M Rossikhina, B S Fyfe, D S Kohtz, J T Fallon, Y Nemerson, M B Taubman

×

Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype.
P W Cook, … , J R Brown, M R Pittelkow
P W Cook, … , J R Brown, M R Pittelkow
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2286-2294. https://doi.org/10.1172/JCI119766.
View: Text | PDF

Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype.

  • Text
  • PDF
Abstract

Research Article

Authors

P W Cook, M Piepkorn, C H Clegg, G D Plowman, J M DeMay, J R Brown, M R Pittelkow

×

Endogenous somatostatin-28 modulates postprandial insulin secretion. Immunoneutralization studies in baboons.
J W Ensinck, … , S E Kahn, D A D'Alessio
J W Ensinck, … , S E Kahn, D A D'Alessio
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2295-2302. https://doi.org/10.1172/JCI119767.
View: Text | PDF

Endogenous somatostatin-28 modulates postprandial insulin secretion. Immunoneutralization studies in baboons.

  • Text
  • PDF
Abstract

Research Article

Authors

J W Ensinck, R E Vogel, E C Laschansky, D J Koerker, R L Prigeon, S E Kahn, D A D'Alessio

×

Pathogenic antibodies inhibit the binding of apolipoproteins to megalin/gp330 in passive Heymann nephritis.
D Kerjaschki, … , M G Farquhar, R A Orlando
D Kerjaschki, … , M G Farquhar, R A Orlando
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2303-2309. https://doi.org/10.1172/JCI119768.
View: Text | PDF

Pathogenic antibodies inhibit the binding of apolipoproteins to megalin/gp330 in passive Heymann nephritis.

  • Text
  • PDF
Abstract

Research Article

Authors

D Kerjaschki, M Exner, R Ullrich, M Susani, L K Curtiss, J L Witztum, M G Farquhar, R A Orlando

×

Angiotensin II stimulates proliferation of normal early erythroid progenitors.
M Mrug, … , J F Prchal, J T Prchal
M Mrug, … , J F Prchal, J T Prchal
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2310-2314. https://doi.org/10.1172/JCI119769.
View: Text | PDF

Angiotensin II stimulates proliferation of normal early erythroid progenitors.

  • Text
  • PDF
Abstract

Research Article

Authors

M Mrug, T Stopka, B A Julian, J F Prchal, J T Prchal

×

Changes in gene expression in the intact human heart. Downregulation of alpha-myosin heavy chain in hypertrophied, failing ventricular myocardium.
B D Lowes, … , E M Gilbert, M R Bristow
B D Lowes, … , E M Gilbert, M R Bristow
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2315-2324. https://doi.org/10.1172/JCI119770.
View: Text | PDF

Changes in gene expression in the intact human heart. Downregulation of alpha-myosin heavy chain in hypertrophied, failing ventricular myocardium.

  • Text
  • PDF
Abstract

Research Article

Authors

B D Lowes, W Minobe, W T Abraham, M N Rizeq, T J Bohlmeyer, R A Quaife, R L Roden, D L Dutcher, A D Robertson, N F Voelkel, D B Badesch, B M Groves, E M Gilbert, M R Bristow

×

Selective inhibition of syncytium-inducing and nonsyncytium-inducing HIV-1 variants in individuals receiving didanosine or zidovudine, respectively.
A B van't Wout, … , J M Lange, H Schuitemaker
A B van't Wout, … , J M Lange, H Schuitemaker
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2325-2332. https://doi.org/10.1172/JCI119771.
View: Text | PDF

Selective inhibition of syncytium-inducing and nonsyncytium-inducing HIV-1 variants in individuals receiving didanosine or zidovudine, respectively.

  • Text
  • PDF
Abstract

Research Article

Authors

A B van't Wout, L J Ran, M D de Jong, M Bakker, R van Leeuwen, D W Notermans, A E Loeliger, F de Wolf, S A Danner, P Reiss, C A Boucher, J M Lange, H Schuitemaker

×

Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease.
M Yaar, … , R E Fine, B A Gilchrest
M Yaar, … , R E Fine, B A Gilchrest
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2333-2340. https://doi.org/10.1172/JCI119772.
View: Text | PDF

Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer's disease.

  • Text
  • PDF
Abstract

Research Article

Authors

M Yaar, S Zhai, P F Pilch, S M Doyle, P B Eisenhauer, R E Fine, B A Gilchrest

×

Germ cell apoptosis after treatment of cryptorchidism with human chorionic gonadotropin is associated with impaired reproductive function in the adult.
L Dunkel, … , J L Tilly, S Wikström
L Dunkel, … , J L Tilly, S Wikström
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2341-2346. https://doi.org/10.1172/JCI119773.
View: Text | PDF

Germ cell apoptosis after treatment of cryptorchidism with human chorionic gonadotropin is associated with impaired reproductive function in the adult.

  • Text
  • PDF
Abstract

Research Article

Authors

L Dunkel, S Taskinen, O Hovatta, J L Tilly, S Wikström

×

Hypoxia inhibits gene expression of voltage-gated K+ channel alpha subunits in pulmonary artery smooth muscle cells.
J Wang, … , L J Rubin, X J Yuan
J Wang, … , L J Rubin, X J Yuan
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2347-2353. https://doi.org/10.1172/JCI119774.
View: Text | PDF

Hypoxia inhibits gene expression of voltage-gated K+ channel alpha subunits in pulmonary artery smooth muscle cells.

  • Text
  • PDF
Abstract

Research Article

Authors

J Wang, M Juhaszova, L J Rubin, X J Yuan

×

Evidence for decreased splanchnic glucose uptake after oral glucose administration in non-insulin-dependent diabetes mellitus.
B Ludvik, … , J M Bell, J M Olefsky
B Ludvik, … , J M Bell, J M Olefsky
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2354-2361. https://doi.org/10.1172/JCI119775.
View: Text | PDF

Evidence for decreased splanchnic glucose uptake after oral glucose administration in non-insulin-dependent diabetes mellitus.

  • Text
  • PDF
Abstract

Research Article

Authors

B Ludvik, J J Nolan, A Roberts, J Baloga, M Joyce, J M Bell, J M Olefsky

×

Myosin heavy chain gene expression in human heart failure.
K Nakao, … , M R Bristow, L A Leinwand
K Nakao, … , M R Bristow, L A Leinwand
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2362-2370. https://doi.org/10.1172/JCI119776.
View: Text | PDF

Myosin heavy chain gene expression in human heart failure.

  • Text
  • PDF
Abstract

Research Article

Authors

K Nakao, W Minobe, R Roden, M R Bristow, L A Leinwand

×

DNA immunization of neonates induces immunity despite the presence of maternal antibody.
E Manickan, … , Z Yu, B T Rouse
E Manickan, … , Z Yu, B T Rouse
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2371-2375. https://doi.org/10.1172/JCI119777.
View: Text | PDF

DNA immunization of neonates induces immunity despite the presence of maternal antibody.

  • Text
  • PDF
Abstract

Research Article

Authors

E Manickan, Z Yu, B T Rouse

×

Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus.
K M Chang, … , A Sette, F V Chisari
K M Chang, … , A Sette, F V Chisari
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2376-2385. https://doi.org/10.1172/JCI119778.
View: Text | PDF

Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus.

  • Text
  • PDF
Abstract

Research Article

Authors

K M Chang, B Rehermann, J G McHutchison, C Pasquinelli, S Southwood, A Sette, F V Chisari

×

Somatostatin receptor (SSTR) subtype-selective analogues differentially suppress in vitro growth hormone and prolactin in human pituitary adenomas. Novel potential therapy for functional pituitary tumors.
I Shimon, … , M D Culler, S Melmed
I Shimon, … , M D Culler, S Melmed
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2386-2392. https://doi.org/10.1172/JCI119779.
View: Text | PDF

Somatostatin receptor (SSTR) subtype-selective analogues differentially suppress in vitro growth hormone and prolactin in human pituitary adenomas. Novel potential therapy for functional pituitary tumors.

  • Text
  • PDF
Abstract

Research Article

Authors

I Shimon, X Yan, J E Taylor, M H Weiss, M D Culler, S Melmed

×

Truncation of the cytoplasmic domain of beta3 in a variant form of Glanzmann thrombasthenia abrogates signaling through the integrin alpha(IIb)beta3 complex.
R Wang, … , D R Ambruso, P J Newman
R Wang, … , D R Ambruso, P J Newman
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2393-2403. https://doi.org/10.1172/JCI119780.
View: Text | PDF

Truncation of the cytoplasmic domain of beta3 in a variant form of Glanzmann thrombasthenia abrogates signaling through the integrin alpha(IIb)beta3 complex.

  • Text
  • PDF
Abstract

Research Article

Authors

R Wang, S J Shattil, D R Ambruso, P J Newman

×

Functional CD40 ligand is expressed by T cells in rheumatoid arthritis.
K P MacDonald, … , P E Lipsky, R Thomas
K P MacDonald, … , P E Lipsky, R Thomas
Published November 1, 1997
Citation Information: J Clin Invest. 1997;100(9):2404-2414. https://doi.org/10.1172/JCI119781.
View: Text | PDF

Functional CD40 ligand is expressed by T cells in rheumatoid arthritis.

  • Text
  • PDF
Abstract

Research Article

Authors

K P MacDonald, Y Nishioka, P E Lipsky, R Thomas

×
Advertisement

Copyright © 2025 American Society for Clinical Investigation
ISSN: 0021-9738 (print), 1558-8238 (online)

Sign up for email alerts