Masakazu Shiota, Mark A. Magnuson
J Clin Invest.
2008;
118(3):841–844
doi:10.1172/JCI35137
This article Copyright © 2008, The American Society for Clinical Investigation
Abstract
|
Full text
|
PDF
I
n this issue of the JCI, Denechaud et al. report studies investigating the role of the liver X receptors (LXRs) LXRα and LXRβ in carbohydrate sensing by the liver (see the related article beginning on page 956). The results of this study, which utilized LXRα/β double-KO mice, strongly contradict a recent Nature report that proposed that LXRα/β sense glucose independent of metabolic flux. The reported findings further support a key role for the carbohydrate-responsive element–binding protein (ChREBP) in the regulation of lipogenic genes by glucose and dietary carbohydrates.
This file is in Adobe Acrobat (PDF) format.
If you have not installed and configured the Adobe Acrobat Reader on your system.
Having trouble reading a PDF?
PDFs are designed to be printed out and read, but if you prefer to read them online, you may find it easier if you increase the view size to 125%.
Having trouble saving a PDF?
Many versions of the free Acrobat Reader do not
allow Save. You must instead save the PDF from the JCI Online page you downloaded it from. PC users:
Right-click on the Download link and choose the option that says something like "Save Link As...".
Mac users should hold the mouse button down on the link to get these same options.
Having trouble printing a PDF?
- Try printing one page at a time or to a newer printer.
- Try saving the file to disk before printing rather than opening it "on the fly." This requires that you
configure your browser to "Save" rather than "Launch Application" for the file type "application/pdf", and can
usually be done in the "Helper Applications" options.
- Make sure you are using the latest version of Adobe's Acrobat Reader.
