High incidence of leukemia in large animals after stem cell gene therapy with a HOXB4-expressing retroviral vector
J. Clin. Invest. Xiao-Bing Zhang, et al. 118:1502 doi:10.1172/JCI34371 [Go to this article.]

Figure 4
Increase in relative marking of leukemic clones over time. Real-time PCR was performed for dogs G374 (A) and G450 (B) and macaque K00339 (C) using LTR- and chromosome-specific primers. Shown are relative values that were normalized to β-actin or GAPDH, which quantify total genomic DNA. Standard curves were generated using a series of 8 dilutions of necropsy marrow DNA samples from each animal. PB, peripheral blood.