Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome
J. Clin. Invest. Kamal Rahmouni, et al. 118:1458 doi:10.1172/JCI32357 [
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Figure 3Change in body weight (
A and
B) and food intake (
C and
D) after i.c.v. administration of vehicle or leptin (5 μg) in
Bbs2–/–,
Bbs4–/–, and
Bbs6–/– mice as compared with wild-type littermate controls.
Data are mean ± SEM;
n = 8–12 mice per group. *
P < 0.05 compared with vehicle;
†P < 0.05 compared with BBS-knockout mice.
