Jules Hirsch
J Clin Invest.
2004;
114(8):1040–1043
doi:10.1172/JCI22993
This article Copyright © 2004, The American Society for Clinical Investigation
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n 1956, the JCI published an article by Vincent Dole on a method for titrating plasma fatty acids that uncovered the importance of fatty acids as a substrate for glucose metabolism. When asked to prepare a historical perspective on this very popular paper, I paid Dole a visit and we reminisced. His answer to my question of how he came to do this work on plasma fatty acids was: “Well, one thing leads to another.” Let me remind the reader of what “things” were like in 1956 and how they might have related to Dole’s important contribution.
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