Vincent Piguet, Quentin Sattentau
J Clin Invest.
2004;
114(5):605–610
doi:10.1172/JCI22812
This article Copyright © 2004, The American Society for Clinical Investigation
Abstract
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ell-to-cell viral transmission facilitates the propagation of HIV-1 and human T cell leukemia virus type 1. Mechanisms of cell-to-cell transmission by retroviruses were not well understood until the recent description of virological synapses (VSs). VSs function as specialized sites of immune cell-to-cell contact that direct virus infection. Deciphering the molecular mechanisms of VS formation provides a fascinating insight into how pathogens subvert immune cell communication programs and achieve viral spread.
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