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Michael J. Owen, Nigel M. Williams, Michael C. O’Donovan
J Clin Invest. 2004;
113(9):1255
doi:10.1172/JCI21470
Abstract |
Full text
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T
he gene encoding dysbindin-1 has recently been implicated in susceptibility to schizophrenia. In this issue of the JCI, Talbot et al. show that, contrary to expectations, dysbindin-1 is located presynaptically in glutamatergic neurons and is reduced at these locations in schizophrenia . Further studies of dysbindin-1 and the proteins with which it interacts can be expected to throw light on the pathogenesis of schizophrenia.
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(7)
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Publication |
Year |
GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia
X Chen, G Lee, B S Maher, A H Fanous, J Chen, Z Zhao, A Guo, E van den Oord, P F Sullivan, J Shi, D F Levinson, P V Gejman, A Sanders, J Duan, M J Owen, N J Craddock, M C O'Donovan, J Blackman, D Lewis, G K Kirov, W Qin, S Schwab, D Wildenauer, K Chowdari, V Nimgaonkar, R E Straub, D R Weinberger, F A O'Neill, D Walsh, M Bronstein, A Darvasi, T Lencz, A K Malhotra, D Rujescu, I Giegling, T Werge, T Hansen, A Ingason, M M Nöethen, M Rietschel, S Cichon, S Djurovic, O A Andreassen, R M Cantor, R Ophoff, A Corvin, D W Morris, M Gill, C N Pato, M T Pato, A Macedo, H M D Gurling, A McQuillin, J Pimm, C Hultman, P Lichtenstein, P Sklar, S M Purcell, E Scolnick, D St Clair, D H R Blackwood, K S Kendler
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Mol Psychiatry
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2010 |
The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis.
Dion K Dickman, Graeme W Davis
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Science
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2009 |
DTNBP1 (Dystrobrevin binding protein 1) and schizophrenia: association evidence in the 3' end of the gene.
Jubao Duan, Maria Martinez, Alan R Sanders, Cuiping Hou, Gregory J Burrell, Aaron J Krasner, Daniel B Schwartz, Pablo V Gejman
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Hum Hered
|
2007 |
Analysis of polymorphisms in AT-rich domains of neuregulin 1 gene in schizophrenia
Herbert M. Lachman, Erika Pedrosa, Karen A. Nolan, Max Glass, Kenny Ye, Takuya Saito
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Am. J. Med. Genet.
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2006 |
Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population
P A Thomson, N R Wray, J K Millar, K L Evans, S Le Hellard, A Condie, W J Muir, D H R Blackwood, D J Porteous
|
Mol Psychiatry
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2005 |
Schizophrenia: An Update and Review
Jehannine Austin
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J Genet Counsel
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2005 |
Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1)
Rachel Raybould, Elaine K. Green, Stuart MacGregor, Katherine Gordon-Smith, Jess Heron, Sally Hyde, Sian Caesar, Ivan Nikolov, Nigel Williams, Lisa Jones, Michael C. O’Donovan, Michael J. Owen, Ian Jones, George Kirov, Nick Craddock
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Biological Psychiatry
|
2005 |
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