Paul M. Sondel, Ilia N. Buhtoiarov, Kenneth DeSantes
J Clin Invest.
2003;
112(1):25–27
doi:10.1172/JCI19095
This article Copyright © 2003, The American Society for Clinical Investigation
Abstract
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G
raft-versus-host disease (GVHD) represents a major cause of morbidity and mortality following conventional allogeneic hematopoietic stem cell transplantation (HSCT). A study in mice (see related article on pages 101–108) demonstrates that the selective administration of donor memory CD4+ T cells results in immune reconstitution without GVHD, a result that, if translatable to humans, has important clinical implications for HSCT.
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