John P. Manis, Frederick W. Alt
J Clin Invest.
2003;
112(1):19–22
doi:10.1172/JCI19091
This article Copyright © 2003, The American Society for Clinical Investigation
Abstract
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Full text
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H
yper-IgM syndrome (HIGM) is a primary immunodeficiency characterized by normal to elevated serum levels of IgM and low levels or the absence of IgG, IgA, and IgE. A new study AID expression in nonlymphoid cells
(see related article on pages
136–142) characterizes HIGM type 4, a previously undocumented defect in antibody gene diversification caused by a selective block in class-switch recombination, providing significant insight towards understanding HIGM immunodeficiencies.
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