Role of Apolipoprotein E-containing Lipoproteins in Abetalipoproteinemia

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Abstract

Detailed studies of apolipoprotein E (apoE)-containing lipoproteins in abetalipoproteinemia have been performed in an attempt to resolve the apparent paradox of a suppressed low density lipoprotein (LDL) receptor pathway in the absence of apoB-containing lipoproteins. It was hypothesized that apoE-containing high density lipoproteins (HDL) in abetalipoproteinemia might functionally substitute for LDL in regulation of cholesterol metabolism in these patients.

Authors

Conrad B. Blum, Richard J. Deckelbaum, Larry D. Witte, Alan R. Tall, Joseph Cornicelli