Studies of the Transferrin Receptor on both Human Reticulocytes and Nucleated Human Cells in Culture: COMPARISON OF FACTORS REGULATING RECEPTOR DENSITY

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Abstract

The transferrin receptor, present on reticulocytes and nucleated cells in tissue culture, has been measured with both immunoassay techniques and transferrin binding studies. The total cellular immunoreactive receptor is rapidly lost from erythrocytes during the process of reticulocyte maturation (from as many as 400,000 molecules to <20,000 molecules/reticulocyte). This event parallels the loss of cell surface transferrin binding sites and RNA content, and correlates with previous studies that have measured the decline in hemoglobin synthesis.

Authors

Janet L. Frazier, Jennifer H. Caskey, Mark Yoffe, Paul A. Seligman