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Clinical Medicine
Author's Take
0 Articles
177 Posts
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Suppression by regulatory T cells and Foxp3-mediated blockage of ryanodine receptor 2
In this episode, Xiaobo Wang, Shuang Geng, and Junchen Meng explain how this work reestablished the suppressive functions in Tconvs absence of Foxp3 indistinguishable from Tregs by simply blocking RyR2 expression...
Published December 15, 2023
Author's Take
Predicting diabetic kidney disease and mediating kidney injury in patients with endogenous adenine
In this episode, Kumar Sharma explains that urine adenine/creatinine is a marker for kidney failure in patients with diabetes, and endogenous adenine plays a potential causative role in diabetic kidney disease...
Published November 2, 2023
Author's Take
A link between serotonin and proliferation is revealed in Cronkhite-Canada syndrome patients
In this episode, Sarah Blutt explains how this work demonstrates the power of organoids to understand and develop new therapies for diseases...
Published November 1, 2023
Author's Take
A model of inherited retinal channelopathy with a nonviral base editing of KCNJ13 mutation
In this episode, Bikash Pattnaik and colleagues explain that their study encompasses the application of genomic medicine to treat monoigenic retinal degeneratiion using base editing genen therapy delivered delivered through novel nonviral platform...
Published October 5, 2023
Author's Take
Cerebrospinal fluid quinolinic acid and delirium and mortality in hip-fracture patients
In this episode, Lasse Giil explains that activation of the kynurenine pathway in delirium leads to high brain concentrations the endogenous neurotoxin quinolinic acid...
Published January 20, 2023
Author's Take
BMX controls in cancer
In this episode, Nima Sharifi and Xiuxiu Li discuss how the BMX kinase regulates androgen and estrogen biosynthesis and is a drug target for sex steroid dependent cancers...
Published January 17, 2023
Author's Take
CD69 expression protects from immune damage after MI
In this episode, Dr. Blanco-DomÃnguez discusses CD69 expression on regulatory T cells after myocardial infarction controls immune homeostasis...
Published November 1, 2022
Author's Take
Durability of AZD1222 COVID-19 vaccine over 6 months
In this episode, Magdalena Sobieszczyk explains the paper and that it provides comprehensive safety information and data on durability of protection and immunogenicity of AZD1222...
Published September 15, 2022
Author's Take
Immune responses and the rejection of colonized solid organ transplants
In this episode, Isabella Pirozzolo explains that following transplantation, microbiota-colonized organs have a shorter half-life than sterile organs. In the paper, the authors show that host-versus-commensal immunity participates in graft damage...
Published September 1, 2022
Author's Take
Targeting hepatic kisspeptin receptors and nonalcoholic fatty liver disease
In this episode, Stephania Guzman explains that this study establishes the kisspeptin receptor as a therapeutic target to treat nonalcoholic fatty liver disease...
Published May 18, 2022
Author's Take
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