Posts

586 items found.
Capillary loss and fibrosis in experimental kidney disease is prevented with TIE2 activation
In this episode, Marie Jeansson explains how the paper's findings suggest that TIE2 activation via angiopoietin-2 (ANGPT2)-binding and TIE2-activating antibody warrants investigation as a therapy in human CKD...
Published November 3, 2025
Video Abstracts
STING-mediated antitumor immunity and CDK12/13 inactivation triggers
In this episode, Yi Bao explains the that the manuscript's findings establish STING activation as the key driver of T cell infiltration and the immune-hot tumor microenvironment in CDK12 mutant cancers...
Published September 16, 2025
Video Abstracts
Spesolimab targets IL-36R to alleviate inflammation and reduce generalized pustular psoriasis flares
In this episode, James G. Kreuger explains that people with generalized pustular psoriasis experience underlying skin inflammation, even in the absence of flares. Spesolimab treatment helps control the inflammation and prevent future flares...
Published September 5, 2025
Video Abstracts
Cyclin D1 overexpression causes replication stress and repair pathway dependence
In this episode, Dr. Jithma Prasad Abeykoon, explains how Cyclin D1 overexpression causes DNA damage and forces cancer cells to depend on targetable repair pathways...
Published September 2, 2025
Video Abstracts
JCI’s Conversations with Giants in Medicine: Ending one conversation
In this final episode of the series, the Conversations with Giants in Medicine series comes to a close...
Published April 1, 2025
Conversations with Giants in Medicine
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