Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer

¹Max Planck Institute for Neurological Research, with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Cologne, Germany. ²Institute of Pathology, University Hospital Medical School, Cologne, Germany. ³Fakultät Chemie, Chemische Biologie, Technische Universität Dortmund, Dortmund, Germany. ⁴Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany. ⁵Departments of Surgery and Pharmacology, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA. ⁶Institute of Biochemistry and Genetics, Department of Biomedicine, Basel, Switzerland. ⁷Department of Translational Genomics, University of Cologne, Cologne, Germany.

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¹Max Planck Institute for Neurological Research, with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Cologne, Germany. ²Institute of Pathology, University Hospital Medical School, Cologne, Germany. ³Fakultät Chemie, Chemische Biologie, Technische Universität Dortmund, Dortmund, Germany. ⁴Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany. ⁵Departments of Surgery and Pharmacology, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA. ⁶Institute of Biochemistry and Genetics, Department of Biomedicine, Basel, Switzerland. ⁷Department of Translational Genomics, University of Cologne, Cologne, Germany.

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¹Max Planck Institute for Neurological Research, with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Cologne, Germany. ²Institute of Pathology, University Hospital Medical School, Cologne, Germany. ³Fakultät Chemie, Chemische Biologie, Technische Universität Dortmund, Dortmund, Germany. ⁴Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany. ⁵Departments of Surgery and Pharmacology, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA. ⁶Institute of Biochemistry and Genetics, Department of Biomedicine, Basel, Switzerland. ⁷Department of Translational Genomics, University of Cologne, Cologne, Germany.

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¹Max Planck Institute for Neurological Research, with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Cologne, Germany. ²Institute of Pathology, University Hospital Medical School, Cologne, Germany. ³Fakultät Chemie, Chemische Biologie, Technische Universität Dortmund, Dortmund, Germany. ⁴Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany. ⁵Departments of Surgery and Pharmacology, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA. ⁶Institute of Biochemistry and Genetics, Department of Biomedicine, Basel, Switzerland. ⁷Department of Translational Genomics, University of Cologne, Cologne, Germany.

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¹Max Planck Institute for Neurological Research, with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Cologne, Germany. ²Institute of Pathology, University Hospital Medical School, Cologne, Germany. ³Fakultät Chemie, Chemische Biologie, Technische Universität Dortmund, Dortmund, Germany. ⁴Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany. ⁵Departments of Surgery and Pharmacology, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA. ⁶Institute of Biochemistry and Genetics, Department of Biomedicine, Basel, Switzerland. ⁷Department of Translational Genomics, University of Cologne, Cologne, Germany.

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¹Max Planck Institute for Neurological Research, with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Cologne, Germany. ²Institute of Pathology, University Hospital Medical School, Cologne, Germany. ³Fakultät Chemie, Chemische Biologie, Technische Universität Dortmund, Dortmund, Germany. ⁴Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany. ⁵Departments of Surgery and Pharmacology, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA. ⁶Institute of Biochemistry and Genetics, Department of Biomedicine, Basel, Switzerland. ⁷Department of Translational Genomics, University of Cologne, Cologne, Germany.

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¹Max Planck Institute for Neurological Research, with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Cologne, Germany. ²Institute of Pathology, University Hospital Medical School, Cologne, Germany. ³Fakultät Chemie, Chemische Biologie, Technische Universität Dortmund, Dortmund, Germany. ⁴Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany. ⁵Departments of Surgery and Pharmacology, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA. ⁶Institute of Biochemistry and Genetics, Department of Biomedicine, Basel, Switzerland. ⁷Department of Translational Genomics, University of Cologne, Cologne, Germany.

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¹Max Planck Institute for Neurological Research, with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Cologne, Germany. ²Institute of Pathology, University Hospital Medical School, Cologne, Germany. ³Fakultät Chemie, Chemische Biologie, Technische Universität Dortmund, Dortmund, Germany. ⁴Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany. ⁵Departments of Surgery and Pharmacology, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA. ⁶Institute of Biochemistry and Genetics, Department of Biomedicine, Basel, Switzerland. ⁷Department of Translational Genomics, University of Cologne, Cologne, Germany.

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¹Max Planck Institute for Neurological Research, with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Cologne, Germany. ²Institute of Pathology, University Hospital Medical School, Cologne, Germany. ³Fakultät Chemie, Chemische Biologie, Technische Universität Dortmund, Dortmund, Germany. ⁴Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany. ⁵Departments of Surgery and Pharmacology, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA. ⁶Institute of Biochemistry and Genetics, Department of Biomedicine, Basel, Switzerland. ⁷Department of Translational Genomics, University of Cologne, Cologne, Germany.

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¹Max Planck Institute for Neurological Research, with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Cologne, Germany. ²Institute of Pathology, University Hospital Medical School, Cologne, Germany. ³Fakultät Chemie, Chemische Biologie, Technische Universität Dortmund, Dortmund, Germany. ⁴Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany. ⁵Departments of Surgery and Pharmacology, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA. ⁶Institute of Biochemistry and Genetics, Department of Biomedicine, Basel, Switzerland. ⁷Department of Translational Genomics, University of Cologne, Cologne, Germany.

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¹Max Planck Institute for Neurological Research, with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Cologne, Germany. ²Institute of Pathology, University Hospital Medical School, Cologne, Germany. ³Fakultät Chemie, Chemische Biologie, Technische Universität Dortmund, Dortmund, Germany. ⁴Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany. ⁵Departments of Surgery and Pharmacology, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA. ⁶Institute of Biochemistry and Genetics, Department of Biomedicine, Basel, Switzerland. ⁷Department of Translational Genomics, University of Cologne, Cologne, Germany.

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¹Max Planck Institute for Neurological Research, with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Cologne, Germany. ²Institute of Pathology, University Hospital Medical School, Cologne, Germany. ³Fakultät Chemie, Chemische Biologie, Technische Universität Dortmund, Dortmund, Germany. ⁴Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany. ⁵Departments of Surgery and Pharmacology, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA. ⁶Institute of Biochemistry and Genetics, Department of Biomedicine, Basel, Switzerland. ⁷Department of Translational Genomics, University of Cologne, Cologne, Germany.

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¹Max Planck Institute for Neurological Research, with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Cologne, Germany. ²Institute of Pathology, University Hospital Medical School, Cologne, Germany. ³Fakultät Chemie, Chemische Biologie, Technische Universität Dortmund, Dortmund, Germany. ⁴Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany. ⁵Departments of Surgery and Pharmacology, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA. ⁶Institute of Biochemistry and Genetics, Department of Biomedicine, Basel, Switzerland. ⁷Department of Translational Genomics, University of Cologne, Cologne, Germany.

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¹Max Planck Institute for Neurological Research, with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Cologne, Germany. ²Institute of Pathology, University Hospital Medical School, Cologne, Germany. ³Fakultät Chemie, Chemische Biologie, Technische Universität Dortmund, Dortmund, Germany. ⁴Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany. ⁵Departments of Surgery and Pharmacology, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA. ⁶Institute of Biochemistry and Genetics, Department of Biomedicine, Basel, Switzerland. ⁷Department of Translational Genomics, University of Cologne, Cologne, Germany.

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¹Max Planck Institute for Neurological Research, with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Cologne, Germany. ²Institute of Pathology, University Hospital Medical School, Cologne, Germany. ³Fakultät Chemie, Chemische Biologie, Technische Universität Dortmund, Dortmund, Germany. ⁴Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany. ⁵Departments of Surgery and Pharmacology, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA. ⁶Institute of Biochemistry and Genetics, Department of Biomedicine, Basel, Switzerland. ⁷Department of Translational Genomics, University of Cologne, Cologne, Germany.

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¹Max Planck Institute for Neurological Research, with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Cologne, Germany. ²Institute of Pathology, University Hospital Medical School, Cologne, Germany. ³Fakultät Chemie, Chemische Biologie, Technische Universität Dortmund, Dortmund, Germany. ⁴Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany. ⁵Departments of Surgery and Pharmacology, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA. ⁶Institute of Biochemistry and Genetics, Department of Biomedicine, Basel, Switzerland. ⁷Department of Translational Genomics, University of Cologne, Cologne, Germany.

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¹Max Planck Institute for Neurological Research, with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Cologne, Germany. ²Institute of Pathology, University Hospital Medical School, Cologne, Germany. ³Fakultät Chemie, Chemische Biologie, Technische Universität Dortmund, Dortmund, Germany. ⁴Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany. ⁵Departments of Surgery and Pharmacology, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA. ⁶Institute of Biochemistry and Genetics, Department of Biomedicine, Basel, Switzerland. ⁷Department of Translational Genomics, University of Cologne, Cologne, Germany.

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¹Max Planck Institute for Neurological Research, with Klaus-Joachim-Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Cologne, Germany. ²Institute of Pathology, University Hospital Medical School, Cologne, Germany. ³Fakultät Chemie, Chemische Biologie, Technische Universität Dortmund, Dortmund, Germany. ⁴Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany. ⁵Departments of Surgery and Pharmacology, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA. ⁶Institute of Biochemistry and Genetics, Department of Biomedicine, Basel, Switzerland. ⁷Department of Translational Genomics, University of Cologne, Cologne, Germany.

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