Breast cancer stem cells, cytokine networks, and the tumor microenvironment
Hasan Korkaya, … , Suling Liu, Max S. Wicha
Hasan Korkaya, … , Suling Liu, Max S. Wicha
Published October 3, 2011
Citation Information: J Clin Invest. 2011;121(10):3804-3809. https://doi.org/10.1172/JCI57099.
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Breast cancer stem cells, cytokine networks, and the tumor microenvironment

Abstract

Many tumors, including breast cancer, are maintained by a subpopulation of cells that display stem cell properties, mediate metastasis, and contribute to treatment resistance. These cancer stem cells (CSCs) are regulated by complex interactions with the components of the tumor microenvironment — including mesenchymal stem cells, adipocytes, tumor associated fibroblasts, endothelial cells, and immune cells — through networks of cytokines and growth factors. Since these components have a direct influence on CSC properties, they represent attractive targets for therapeutic development.

Authors

Hasan Korkaya, Suling Liu, Max S. Wicha

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Figure 1

The tumor microenvironment.

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The tumor microenvironment. Elevated levels of cytokines and growth fact...
Elevated levels of cytokines and growth factors produced by tumor cells enhance the proliferation and survival of CSCs, induce angiogenesis, and recruit tumor-associated macrophages, neutrophils, and mast cells, which secrete additional growth factors, forming a positive feedback loop that promotes tumor cell invasion and metastasis.