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Abstract

The role of adherent-invasive E. coli (AIEC) in Crohn disease (CD) has been in debate for decades. AIEC bacteria are found in the small intestine of patients with chronic CD, but it has remained unclear whether this infection is causal or secondary to underlying immune deficiencies in CD patients. In this issue of the JCI, Chassaing and colleagues demonstrate that AIEC bacteria express an adherence factor called long polar fimbriae (LPF) that aids in the binding of these bacteria to M cells overlying Peyer’s patches and subsequent entry into lymphoid tissue. These findings provide a mechanism of AIEC penetration but do not prove that AIEC is causing a primary infection in the Peyer’s patches that is necessary for the initiation or persistence of CD inflammation.

Authors

Warren Strober

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Total citations by year

Year: 2013 2012 2011 Total
Citations: 3 2 2 7
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Citations to this article (7)

Title and authors Publication Year
Pathogenesis of adherent–invasive Escherichia coli
EJ Smith, AP Thompson, A O‘Driscoll, DJ Clarke
Future Microbiology 2013
Impact of the gut microbiome on mucosal inflammation
W Strober
Trends in Immunology 2013
Escherichia Coli
SK Vanaja, DM Jandhyala, EM Mallick, JM Leong, S Balasubramanian
Escherichia Coli 2013
AIEC colonization and pathogenicity: Influence of previous antibiotic treatment and preexisting inflammation
M Drouet, C Vignal, E Singer, M Djouina, L Dubreuil, A Cortot, P Desreumaux, C Neut
Inflammatory Bowel Diseases 2012
Immunomodulation for gastrointestinal infections
RJ Cieza, AT Cao, Y Cong, AG Torres
Expert Review of Anti-infective Therapy 2012
Characterization of adherent-invasive Escherichia coli isolated from pediatric patients with inflammatory bowel disease
A Negroni, M Costanzo, R Vitali, F Superti, L Bertuccini, A Tinari, F Minelli, GD Nardo, F Nuti, M Pierdomenico, S Cucchiara, L Stronati
Inflammatory Bowel Diseases 2011
NOD2, an intracellular innate immune sensor involved in host defense and Crohn's disease
W Strober, T Watanabe
Mucosal Immunology 2011

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