De novo lipogenesis is unchanged in 4-week-old JAK2L mice.
Total palmitate (A) and glycerol (D) content of JAK2L and control livers as determined by direct measurement expressed as μmol/g tissue. Fractional new synthesis of palmitate (B) and glycerol (E) in JAK2L and control livers was assessed after injection of 2H2O and determination of 2H labeling by mass spectrometry. Absolute amount of new palmitate (C) and glycerol (F) synthesized during the 4-hour labeling period expressed as μmol/g tissue. All values are expressed as mean ± SEM (n = 6–9 for both groups). *P = 0.048, **P = 0.0246, ***P = 0.0024.