A HapMap harvest of insights into the genetics of common disease
J. Clin. Invest. Teri A. Manolio, et al. 118:1590 doi:10.1172/JCI34772 [Go to this article.]

Figure 2
Breakdown of LD around a new SNP. A mutation generating a novel SNP (red circle) occurs on an existing chromosome (dark blue) with multiple preexisting SNP alleles (dark blue circles) occurring in an ancestral haplotype that spans the entire chromosomal segment shown. After multiple meioses over many generations (arrows), the chromosomal segments flanking this variant will tend to be reshuffled by recombination, as shown by different colors. Over time, therefore, the segment containing the new variant and its surrounding ancestral SNP alleles becomes shorter and occurs on a variety of haplotypes associated with different flanking SNP alleles.