Complex two-gene modulation of lung disease severity in children with cystic fibrosis
J. Clin. Invest. Ruslan Dorfman, et al. 118:1040 doi:10.1172/JCI33754 [
Go to this article.]
Figure 2Results of time-to-event analysis showing median age and 95% CI at first positive culture for
P. aeruginosa.
The proportion of patients not infected with
P. aeruginosa versus age is plotted for low
MBL2 (**00 and XYA0;
n = 136), intermediate
MBL2 (YYA0 and XXAA;
n = 311), and high
MBL2 (YYAA and XYAA;
n = 572) diplotype groups. The graph shows data for 1,019 pediatric (<18.5 years of age) PI CF patients. Median age of infection was 4.4 yr (95% CI, 3.2 to 6.4 yr) for the low
MBL2 group, 7.0 yr (95% CI, 6.1 to 7.9 yr) for the intermediate
MBL2 group, and 8.0 yr (95% CI, 7.2 to 8.8 yr) for the high
MBL2 group. The survival probability differences were tested using log-rank test (
P = 0.0003).
