VEGF-B inhibits apoptosis via VEGFR-1–mediated suppression of the expression of BH3-only protein genes in mice and rats
J. Clin. Invest. Yang Li, et al. 118:913 doi:10.1172/JCI33673 [Go to this article.]

Figure 1
VEGF-B₁₆₇ inhibits the expression of the BH3-only protein and other apoptotic/cell death–related genes in multiple cell lines. (A) VEGF-B₁₆₇ treatment inhibited the expression of the BH3-only protein (Bmf, Hrk, Puma, Bid, Bik, Noxa) and other apoptotic/cell death–related genes in the rat RGC-derived cell line RGC5 according to real-time PCR assay. (B) VEGF-B₁₆₇ treatment inhibited the expression of the BH3-only protein (Hrk, Bik, Bid, Bmf, Noxa) and other apoptotic/cell death–related genes in the immortalized rat retinal pericyte cell line TR-rPCT. (C) VEGF-B₁₆₇ treatment inhibited the expression of the BH3-only protein (Bmf, Bik, Noxa, Bid, Hrk) and other apoptotic/cell death–related genes in the immortalized rat retinal Müller cell line TR-MUL. (D) VEGF-B₁₆₇ treatment inhibited the expression of the BH3-only protein (Bik, Bid, Hrk, Noxa, Puma) and other apoptotic/cell death–related genes in the immortalized rat retinal endothelial cell line TR-iBRB. (E) VEGF-B₁₆₇ treatment inhibited the expression of the BH3-only protein (Bid, Bik, Bbc3, Bad, Hrk, Noxa, Bmf) and other apoptotic/cell death–related genes in mouse primary aortic smooth muscle cells (mSMC).