Impaired parasympathetic function increases susceptibility to inflammatory bowel disease in a mouse model of depression
J. Clin. Invest. Jean-Eric Ghia, et al. 118:2209 doi:10.1172/JCI32849 [Go to this article.]

Figure 2
Influence of experimental design on colitis. (A) Effects of reserpine (1 μg/d for 14 days, ICV-R) treatment versus vehicle (ICV-C) on the DAI during the development of DSS-induced colitis in mice over 5 days. Mice were given 5% DSS solution in the drinking water to induce colitis 9 days after the beginning of the reserpine treatment. Reserpine increased the DAI (n = 12). (B) Macroscopic scores were higher in RM (n = 12). (C) MPO activity was higher in RM (n = 12). (D) CRP, an acute inflammatory marker, was measured by ELISA. A significant increase of CRP was detected in the RM group compared with the sham-operated group (ICV-C) (n = 12). The values are shown as means ± SEM. *P < 0.05 compared with ICV-C group.