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Devon A. Lawson, Owen N. Witte
J Clin Invest. 2007;
117(8):2044
doi:10.1172/JCI32810
Abstract |
Full text
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P
eter Nowell and David Hungerford’s discovery of the Philadelphia chromosome facilitated many critical studies that have led to a paradigm shift in our understanding of cancer as a disease of stem cells. This Review focuses on the application of these concepts to investigation of the role of stem cells in prostate cancer initiation and progression. Major strides in the development of in vitro and in vivo assays have enabled identification and characterization of prostate stem cells as well as functional evaluation of the tumorigenic effects of prostate cancer–related genetic alterations.
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Citations to this article
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(42)
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Year |
Adult Murine Prostate Basal and Luminal Cells Are Self-Sustained Lineages that Can Both Serve as Targets for Prostate Cancer Initiation
Nahyun Choi, Boyu Zhang, Li Zhang, Michael Ittmann, Li Xin
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Cancer Cell
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2012 |
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Hangwen Li, Dean G. Tang
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J. Surg. Oncol.
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2011 |
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Naomi L. Dunning, Stéphanie A. Laversin, Amanda K. Miles, Robert C. Rees
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Cancer Immunol Immunother
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2011 |
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Juan Wang, Zhi-qun Shang, Yuan-jie Niu
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Clin. Oncol. Cancer Res.
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2011 |
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Molecular and Cellular Endocrinology
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2011 |
Targeting the cancer initiating cell: The Achilles’ heel of cancer
James A. McCubrey, William H. Chappell, Stephen L. Abrams, Richard A. Franklin, Jacquelyn M. Long, Jennifer A. Sattler, C. Ruth Kempf, Piotr Laidler, Linda S. Steelman
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Advances in Enzyme Regulation
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2011 |
Characterization of sphere-propagating cells with stem-like properties from DU145 prostate cancer cells
Adrian P. Rybak, Lizhi He, Anil Kapoor, Jean-Claude Cutz, Damu Tang
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Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
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2011 |
Chemopreventive effects of tea in prostate cancer: Green tea versus black tea
Susanne M. Henning, Piwen Wang, David Heber
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Mol. Nutr. Food Res.
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2011 |
FGFR1 abrogates inhibitory effect of androgen receptor concurrent with induction of androgen-receptor variants in androgen receptor-negative prostate tumor epithelial cells
Masashi Kobayashi, Yanqing Huang, Chengliu Jin, Yongde Luo, Tetsuji Okamoto, Fen Wang, Wallace L. McKeehan
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Prostate
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2011 |
Expression analysis of putative stem cell markers in human benign and malignant prostate
Andrey V. Ugolkov, Laurie J. Eisengart, Chunyan Luan, Ximing J. Yang
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Prostate
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2011 |
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