Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis
J. Clin. Invest. Shahla Abdollahi-Roodsaz, et al. 118:205 doi:10.1172/JCI32639 [
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Figure 3Higher severity and increased histopathology of
IL1rn–/– arthritis caused by
Tlr2 deficiency.
Percentage incidence (
A) and severity score (
B) of arthritis in
IL1rn–/–Tlr2+/+ mice compared with
IL1rn–/–Tlr2–/– littermates. Severity was scored macroscopically on a scale of 0–2 for each paw;
n > 20 mice per group. (
C) Histological assessment of the ankle joints at 15 weeks (mean ± SEM) on a scale between 0 and 3 for each parameter;
n = 14 mice per group. (
D) Representative histological images of ankle joints. Cell influx and chondrocyte death were scored on H&E-stained (top row), and cartilage and bone damage (arrows) were scored on safranin O–stained (bottom row) tissue sections. PG depletion is apparent from loss of red staining. Original magnification, ×50 for H&E and ×100 for safranin O staining. B, bone; C, cartilage; JS, joint space; S, synovium. *
P < 0.05 and **
P < 0.01.
