Adoptive T cell therapy for cancer in the clinic
J. Clin. Invest. Carl H. June, et al. 117:1466 doi:10.1172/JCI32446 [Go to this article.]

Figure 2
Suicide T cell therapy using adoptively transferred T cells. T cells can be engineered to express conditional suicide switches so that the T cells die when a drug is administered that activates the switch and causes apoptosis. Suicide constructs have been incorporated into allogeneic T cells that can be ablated in the event of GVHD and into autologous T cells that can be ablated in the event of toxicity or uncontrolled T cell proliferation.